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Carcinogenesis Advance Access published online on August 14, 2003
Carcinogenesis, doi:10.1093/carcin/bgg133
© 2003 by Oxford University Press
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© 2003 Oxford University Press

CARCINOGENESIS

Gene expression profile of normal lungs predicts genetic predisposition to lung cancer in mice

Manuela Gariboldi 1, Monica Spinola 2, Silvano Milani 3, Carmen Pignatiello 2, Koji Kadota 4, Hidemasa Bono 5, Yoshihide Hayashizaki 5, Tommaso A. Dragani 2*, and Yasushi Okazaki 5*

1 Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy; Laboratory for Genome Exploration Research Group, RIKEN, Yokohama, Japan
2 Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
3 Institute of Medical Statistics and Biometry, University of Milan, Milan, Italy
4 Laboratory for Genome Exploration Research Group, RIKEN, Yokohama, Japan; University of Tokyo, Tokyo, Japan
5 Laboratory for Genome Exploration Research Group, RIKEN, Yokohama, Japan

* Corresponding author. E-mail: okazaki{at}saitamamed.ac.jp.

Received 9 April 2003 ; revised 25 June 2003 ; accepted 25 July 2003

Abstract

Genetic susceptibility to lung tumorigenesis shows large variations among mouse strains. To test whether genetic predisposition to lung tumorigenesis is associated with a specific gene expression profile in normal lungs, we analyzed gene expression in 16 inbred strains of known susceptibility/resistance to lung tumorigenesis, using the RIKEN mouse full-length cDNA 19K microarray set. The strain-specific expression profile of 91 cDNA clones correlated with strain lung tumor susceptibility/resistance and predicted, by principal component analysis, the genetic predisposition to lung tumorigenesis in mice.

genetic susceptibility, inbred strains, lung tumors, cDNA microarray
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