Carcinogenesis Advance Access published online on October 10, 2003
Carcinogenesis, doi:10.1093/carcin/bgg189
© 2003 by Oxford University Press
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION
1 Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
* Corresponding author. E-mail: annawu{at}hsc.usc.edu.
Received 1 July 2003
; revised 3 September 2003
; accepted 25 September 2003
In a case-control study conducted among Asian-American women in Los Angeles County, we reported that the risk of breast cancer was significantly reduced in association with soy intake [Wu, A.H., Wan, P., Hankin, J., et al. (2002) Carcinogenesis 23: 1491-1496]. In a subset of cases (n=97) and controls (n=97), we investigated the relationship between self-reported usual adult intake of soy isoflavones which was determined from a food frequency questionnaire and levels of plasma isoflavones (genistein, daidzein) and isoflavone metabolites (equol, dihydrogenistein, dihydrodaidzein) from a randomly-timed blood specimen. In analyses conducted in cases and controls separately, levels of plasma genistein, daidzein and total isoflavones increased with increasing levels of self-reported intake of soy isoflavones. Breast cancer cases and control subjects did not differ in their respective associations between total plasma isoflavone levels and self-reported intake (p=0.48). Among all subjects, there was a 3-fold difference in geometric mean plasma levels of total isoflavones [81.8 nmol/L (95% CI=53.4, 125.1) vs 26.4 nmol/L (95% CI=16.6, 41.8)] between women in the highest quartile of soy isoflavone intake (>12.68 mg of isoflavones per 1000 kcal) compared to those in the lowest (
Plasma isoflavone levels versus self-reported soy isoflavone levels in Asian American women in Los Angeles County
2 National Center for Toxicological Research, Jefferson, Arkansas
1.79 mg of isoflavones per 1000 kcal) quartile of intake, a difference that was statistically significant (p=0.002). The present study provides independent corroboration that breast cancer cases and control subjects can reliably recall their usual soy intake, and that there is no evidence of selective recall biases between breast cancer cases and controls. These results further strengthen our previous observation of an inverse association between soy intake and breast cancer risk in the Los Angeles Asian Breast Cancer Study.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. J. Fuhrman, R. Pfeiffer, X. Xu, A. H. Wu, L. Korde, M. H. Gail, L. K. Keefer, T. D. Veenstra, R. N. Hoover, and R. G. Ziegler Soy Intake is Associated with Increased 2-Hydroxylation and Decreased 16{alpha}-Hydroxylation of Estrogens in Asian-American Women Cancer Epidemiol. Biomarkers Prev., October 1, 2009; 18(10): 2751 - 2760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Wu, M. C. Pike, L. D. Williams, D. Spicer, C.-C. Tseng, M. I. Churchwell, and D. R. Doerge Tamoxifen, Soy, and Lifestyle Factors in Asian American Women With Breast Cancer J. Clin. Oncol., July 20, 2007; 25(21): 3024 - 3030. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A Franke, B. M Halm, L. J Custer, Y. Tatsumura, and S. Hebshi Isoflavones in breastfed infants after mothers consume soy. Am. J. Clinical Nutrition, August 1, 2006; 84(2): 406 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Atkinson, C. L. Frankenfeld, and J. W. Lampe Gut Bacterial Metabolism of the Soy Isoflavone Daidzein: Exploring the Relevance to Human Health Experimental Biology and Medicine, March 1, 2005; 230(3): 155 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Scallet, R. L. Divine, R. R. Newbold, and K. B. Delclos Increased Volume of the Calbindin D28k-Labeled Sexually Dimorphic Hypothalamus in Genistein and Nonylphenol-Treated Male Rats Toxicol. Sci., December 1, 2004; 82(2): 570 - 576. [Abstract] [Full Text] [PDF]
|
|