Carcinogenesis Advance Access published online on October 24, 2003
Carcinogenesis, doi:10.1093/carcin/bgh002
© 2003 by Oxford University Press
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MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION
1 Department of Nutrition and the Harvard Center for Cancer Prevention, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115, USA
* Corresponding author. E-mail: jhan{at}hsph.harvard.edu.
Received 2 June 2003
; revised 29 September 2003
; accepted 14 October 2003
Genetic polymorphisms in double strand break repair genes may influence DNA repair capacity, and in turn confer predisposition to breast cancer. We prospectively assessed the associations of candidate polymorphisms G31479A (R188H) in XRCC2, A4541G (5'-UTR), A17893G (IVS5-14), and C18067T (T241M) in XRCC3, and C299T (5'-UTR) and T1977C (D501D) in Ligase IV with breast cancer risk in a nested case-control study within the Nurses' Health Study (incident cases, n=1004; controls, n=1385). We observed no overall associations of these six genotypes with breast cancer risk. Four common haplotypes in XRCC3 accounted for 99% of the chromosomes of the present study population. We observed that Ligase IV 1977C carriers were at increased breast cancer risk if they had a first-degree family history of breast cancer (P, test for interaction, =0.01). We observed that the XRCC2 R188H polymorphism modified the association of plasma
XRCC2, XRCC3, Ligase IV, DNA repair, haplotype, carotenoid, smoking, breast cancer
Polymorphisms in DNA double strand break repair genes and breast cancer risk in the nurses' health study
2 Department of Epidemiology, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, 181 Longwood Ave., Boston, MA 02115
3 Harvard Center for Cancer Prevention, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115
4 Department of Epidemiology and the Harvard Center for Cancer Prevention, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, 181 Longwood Ave., Boston, MA 02115
5 Departments of Nutrition and Epidemiology, and the Harvard Center for Cancer Prevention, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, 181 Longwood Ave., Boston, MA 02115
-carotene level and breast cancer risk (P, test for ordinal interaction, =0.03); the significantly decreased risk seen overall for women in the highest quartile of plasma -carotene was only present among 188H non-carriers (the top quartile versus the bottom quartile; multivariate odds ratio, 0.55; 95% confidence interval, 0.40-0.75). No significant interactions were seen between any of these polymorphisms and duration or dose of cigarette smoking. The gene-environment interaction data suggest that the subtle effects of some of these variants on breast cancer risk may be magnified in the presence of certain exposures.
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