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Carcinogenesis Advance Access published online on November 6, 2003
Carcinogenesis, doi:10.1093/carcin/bgh015
© 2003 by Oxford University Press
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© 2003 Oxford University Press

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION

A partial allelotyping of urothelial carcinoma of bladder in the Chinese

Jianjun Zhang 1, Shan Zheng 2, Yanning Gao 1, Jimmy A. Rotolo 3, Zejun Xiao 4, Changling Li 4, and Shujun Cheng 1*

1 Department of Chemical Etiology and Carcinogenesis, Cancer Institute (Hospital), Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China
2 Department of Pathology, Cancer Institute (Hospital), Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China
3 Department of Pharmacology, Joan and Sanford I. Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10021
4 Department of Urology, Cancer Institute (Hospital), Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China

* Corresponding author. E-mail: chengsj{at}pubem.cicams.ac.cn.

Received 27 February 2003 ; revised 24 September 2003 ; accepted 28 October 2003

Abstract

The cancer spectrum and genetic pathways underlying tumorigenesis vary among different ethnic populations due to genetic-background and/or environment discrepancies. We have implied in our previous study that the genetic alterations found in bladder cancers of Chinese patients differ from those of Caucasians. We performed the present study to explore the genetic pathways of the urothelial carcinoma (UC) in Chinese patients. We carried out a partial allelotyping of Chinese UC on chromosome arms commonly deleted in Caucasian UC, and compared the allelotyping between Chinese and Caucasian UC. Forty-five Chinese UC specimens were allelotyped using 30 microsatellite markers on 18 chromosome arms. The most frequent regions of LOH found included 9q (54.1%), 17p (51.2%), 9p (48.8%), 18q (42.2%), 3p (41.9%), 16q (33.5%) and 11p (30.0%). Compared with UC from the UK and US, the LOH frequencies on most chromosome arms in this study are higher, with statistically significant differences on 3p, 16q and 18q. Our results suggest that both consensus and different alterations exist between Chinese and Caucasian UC, indicating that genetic alterations of cancer can vary between different ethnic populations due to genetic and/or etiological discrepancies.

allelotyping, urothelial carcinoma, Chinese population, etiology
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