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Carcinogenesis Advance Access published online on February 4, 2004
Carcinogenesis, doi:10.1093/carcin/bgh099
© 2004 by Oxford University Press
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© 2004 Oxford University Press

CANCER BIOLOGY

p53 protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis

Toshiyuki Habu 1, Nobunao Wakabayashi 1, Kayo Yoshida 2, Kenntaro Yomogida 3, Yoshitake Nishimune 3, and Takashi Morita 2*

1 Department of Molecular Embryology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565, Japan
2 Department of Molecular Genetics, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno, Osaka 545-8585, Japan
3 Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565, Japan

* Corresponding author. E-mail: tmorita{at}med.osaka-cu.ac.jp.

Received 1 August 2003 ; revised 15 January 2004 ; accepted 17 January 2004

Abstract

The tumor suppressor protein p53 is specifically expressed during meiosis in spermatocytes. Subsets of p53 knockout mice exhibit testicular giant cell degenerative syndrome, which suggests p53 may be associated with meiotic cell cycle and/or DNA metabolism. Here, we show that p53 binds to the mouse meiosisspecific RecA-like protein Mus musculus DMC1 (MmDMC1). The C-terminal domain (amino acid 234-340) of MmDMC1 binds to DNA-binding domain of p53 protein. p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells.


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