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Carcinogenesis Advance Access published online on February 4, 2004
Carcinogenesis, doi:10.1093/carcin/bgh104
© 2004 by Oxford University Press
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© 2004 Oxford University Press

CARCINOGENESIS

Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinomas

David Meierhofer 1, Johannes A. Mayr 1, Ulrike Foetschl 1, Alexandra Berger 1, Klaus Fink 2, Nikolaus Schmeller 2, Gerhard W. Hacker 3, Cornelia Hauser-Kronberger 4, Barbara Kofler 1*, and Wolfgang Sperl 1

1 Department of Pediatrics, General Hospital Salzburg, Muellner Hauptstr. 48, A-5020 Salzburg, Austria
2 Department of Urology, General Hospital Salzburg, Muellner Hauptstr. 48, A-5020 Salzburg, Austria
3 Research Institute for Frontier Questions of Medicine and Biotechnology, General Hospital Salzburg, Muellner Hauptstr. 48, A-5020 Salzburg, Austria
4 Institute of Pathology, General Hospital Salzburg, Muellner Hauptstr. 48, A-5020 Salzburg, Austria

* Corresponding author. E-mail: B.Kofler{at}lks.at.

Received 28 July 2003 ; revised 30 December 2003 ; accepted 26 January 2004

Abstract

To elucidate the relationship between tumorgenesis and the mitochondrial energy metabolism in renal neoplasms, we studied three individual enzyme activities of the oxidative phosphorylation, two components of the Krebs cycle and the mitochondrial DNA content of renal carcinomas including 29 conventional, 5 papillary, 2 unclassified carcinomas with sarcomatoid features and one collecting duct carcinoma. A significant reduction of all mitochondrial enzyme activities including complex V, as well as of the mitochondrial DNA content was detected in 34 of 37 renal carcinoma tissues as compared to control kidney. Mitochondrial enzyme activities and mitochondrial DNA levels were not statistically different between the conventional, papillary and unclassified sarcomatoid type of renal carcinoma and did not correlate with tumor grade, metastasis, ploidy and proliferative activity as determined by Ki-67 staining. Taken together, our data indicate that a co-ordinated down-regulation of all components necessary for mitochondrial energy metabolism occurs in most renal carcinomas as an early event in carcinoma formation which does not change with progression of the disease.


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