Skip Navigation



Carcinogenesis Advance Access published online on February 19, 2004
Carcinogenesis, doi:10.1093/carcin/bgh124
© 2004 by Oxford University Press
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
25/7/1299    most recent
bgh124v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by López-Nieva, P.
Right arrow Articles by Fernández-Piqueras, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by López-Nieva, P.
Right arrow Articles by Fernández-Piqueras, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2004 Oxford University Press

CARCINOGENESIS

Altered expression of Notch1, Notch2, c-Myc and Ikaros in {gamma}-radiation induced mouse thymic lymphomas

P. López-Nieva 1, J. Santos 1, and J. Fernández-Piqueras 1*

1 Laboratorio de Genética Molecular Humana, Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049-Madrid, España

* Corresponding author. E-mail: jf.piqueras{at}uam.es.

Received 12 January 2004 ; revised 9 February 2004 ; accepted 10 February 2004

Abstract

Gamma-radiation induced thymic lymphomas constitute a heterogeneous group of T-cell lymphomas. Some tumour suppressor genes and oncogenes have been shown to be defective in a fraction of such lymphomas, yet a considerable number of these remains elusive in terms of gene alterations. In the present work we present evidence that {gamma}-radiation induced thymic lymphomas in (C57BL/6J x BALB/c) F1 hybrid mice often exhibit increased levels of Notch1 expression, but, contrary to what was expected, they also exhibit a clearly reduced Notch2 mRNA expression, suggesting a cooperative antagonism of these genes. These results represent the first reported instance for the involvement of Notch2 inactivation in the development of thymic primary tumours while confirming the role of Notch1 as an activated oncogene. Additional analyses revealed that c-Myc over-expression and partial inactivation of Znfn1a1/Ikaros appear to be relevant events. Taken together, these results show that most of the tumours (81.25%) simultaneously experience activation of both Notch1 and c-Myc, inactivation of Notch2 and diminished Znfn1a1/Ikaros DNA-binding activity. Thus, we propose that these alterations might be collaborating in promoting primary thymic lymphomas in mice treated with {gamma}-irradiation.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
S. Chari and S. Winandy
Ikaros Regulates Notch Target Gene Expression in Developing Thymocytes
J. Immunol., November 1, 2008; 181(9): 6265 - 6274.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. L. Kathrein, S. Chari, and S. Winandy
Ikaros Directly Represses the Notch Target Gene Hes1 in a Leukemia T Cell Line: IMPLICATIONS FOR CD4 REGULATION
J. Biol. Chem., April 18, 2008; 283(16): 10476 - 10484.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Konishi, K. S. Kawaguchi, H. Vo, N. Haruki, A. Gonzalez, D. P. Carbone, and T. P. Dang
{gamma}-Secretase Inhibitor Prevents Notch3 Activation and Reduces Proliferation in Human Lung Cancers
Cancer Res., September 1, 2007; 67(17): 8051 - 8057.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. G. Leong and A. Karsan
Recent insights into the role of Notch signaling in tumorigenesis
Blood, March 15, 2006; 107(6): 2223 - 2233.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Dumortier, R. Jeannet, P. Kirstetter, E. Kleinmann, M. Sellars, N. R. dos Santos, C. Thibault, J. Barths, J. Ghysdael, J. A. Punt, et al.
Notch Activation Is an Early and Critical Event during T-Cell Leukemogenesis in Ikaros-Deficient Mice
Mol. Cell. Biol., January 1, 2006; 26(1): 209 - 220.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.