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Carcinogenesis Advance Access published online on March 4, 2004
Carcinogenesis, doi:10.1093/carcin/bgh132
© 2004 by Oxford University Press
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© 2004 Oxford University Press

CANCER BIOLOGY

Akt mediates an angiogenic switch in transformed keratinocytes

Carmen Segrelles 1, Sergio Ruiz 1, Mirentxu Santos 1, Jesús Martínez-Palacio 1, M. Fernanda Lara 1, and Jesús M. Paramio 1*

1 Department of Cell and Molecular Biology, CIEMAT, Av. Complutense 22, E-28040 Madrid, Spain

* Corresponding author. E-mail: jesusm.paramio{at}ciemat.es.

Received 6 November 2003 ; revised 5 February 2004 ; accepted 20 February 2004

Abstract

Akt signaling is involved in tumorigenesis via a number of different mechanisms that result in increased proliferation and decreased apoptosis. Previous data have demonstrated that Akt-mediated signaling is functionally involved in keratinocyte transformation. This work investigates the involvement of angiogenesis as a mediator of tumorigenesis in Akt-transformed keratinocytes. Tumors produced by subcutaneous injection of the latter showed increased angiogenic profiles associated with increased VEGF protein levels. However, in contrast to v-rasHa-transformed keratinocytes, VEGF mRNA levels were not increased. The induction of VEGF protein by Akt is associated with increased phosphorylation and thus activation of p70S6K and 4E-BP1, leading to increased VEGF translation. In addition, we observed increased MMP2 and MMP9 expression, but not TSP1, in tumors derived from Akt-transformed keratinocytes. Collectively, these results demonstrate that Akt is an important mediator of angiogenesis in malignant keratinocytes through a post-transcriptional mechanism.


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