Carcinogenesis Advance Access published online on April 16, 2004
Carcinogenesis, doi:10.1093/carcin/bgh172
© 2004 by Oxford University Press
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1 Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
* To whom correspondence should be addressed. E-mail: hrmelcl{at}hkucc.hku.hk.
The role of hepatitis B virus (HBV) genotypes, core promoter (CP) and precore mutants on hepatocellular carcinoma (HCC) is still controversial. We aimed to determine their role on the development and clinical features of HCC. HBV genotypes and CP/ precore mutations were determined in 90 HCC patients and 180 matched control patients. In the 90 HCC patients, 22 (24.4%) and 68 (75.6%) had subtype Ba and genotype C respectively. The prevalence of genotype C and CP mutations was significantly higher in HCC patients compared to controls (75.6% vs. 57.8%, p=0.004; 90.9% vs. 74.8% respectively, p=0.007). Among carriers of genotype C, 91.8% of the HCC patients and 88.8% of controls had CP mutations. Among carriers of subtype Ba, HCC patients had a higher prevalence of CP mutations compared to controls (88.2% vs. 54.5% respectively, p=0.02). By logistic regression analysis, the only factor associated with HCC was mutation of CP region (p=0.032). There were no differences in the clinical features on presentation, the chance of receiving treatment and the cumulative survival rate for chemoembolization-treated patients between patients with subtype Ba and genotype C. There was too small number of CP wild-type to do a similar comparison with CP mutants. In conclusion, there was a significantly higher prevalence of both genotype C and CP mutations in patients with HCC. The association between HBV genotype C and HCC was probably not genuine but was due to the high percentage of CP mutations in patients with genotype C. Key Words:
hepatitis B virus, genotype, hepatocellular carcinoma, case control study, treatment
Revised April 1, 2004
Accepted April 9, 2004
CANCER BIOLOGY
Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutationson hepatocellular carcinoma: a case control study
2 Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, Nagoya 467-8601, Japan
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