Carcinogenesis Advance Access published online on June 3, 2004
Carcinogenesis, doi:10.1093/carcin/bgh197
© 2004 by Oxford University Press
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1 Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
* To whom correspondence should be addressed. E-mail: qwei{at}mdanderson.org.
p73, a novel p53 homologue, has some p53-like activity and plays an important role in modulating cell-cycle control, apoptosis, and cell growth. p73 regulates differentiation of head and neck squamous epithelium, and changes in p73 may lead to the development of squamous cell carcinoma of the head and neck (SCCHN). Two linked non-coding exon 2 polymorphisms (designated as G4C14-to-A4T14) were recently identified but its functional relevance is unknown. We hypothesized that this polymorphism plays a role in the etiology of SCCHN. Therefore, in this hospital-based case-control study of 708 patients newly diagnosed with SCCHN and 1229 cancer-free controls, we evaluated the association between the p73 AT variant allele and risk of SCCHN. The controls were frequency-matched to the cases by age (±5 years), sex, and smoking status, and all subjects were non-Hispanic whites. Our results showed that the frequencies of variant AT allele and genotypes were more common in the cases than in the controls (P=0.029 and P=0.009, respectively). Compared with the GC/GC genotype, the variant genotypes (GC/AT+AT/AT) were associated with a statistically significantly increased risk for SCCHN (odds ratio (OR) = 1.33, 95% confidence interval (CI) = 1.10-1.60). Further stratification analyses by age, sex, and smoking and alcohol status and by cancer sites within the head and neck region indicated that this significantly increased risk was more pronounced in younger ( Key Words:
Cell cycle, genetic susceptibility, polymorphism, oral cancer, molecular Epidemiology
Revised May 18, 2004
Accepted May 25, 2004
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION
Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck
2 Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030; Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
3 Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
4 Department of Thoracic and Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
Abstract 
50 years) individuals (adjusted OR=1.70; 95% CI, 1.19-2.43), women (1.61; 1.09-2.37), current smokers (1.77; 1.25-2.51), and patients with oral cancer (1.54; 1.15-2.07). Our results suggest that this p73 polymorphism may be a risk marker for genetic susceptibility to SCCHN.
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