Carcinogenesis Advance Access published online on July 22, 2004
Carcinogenesis, doi:10.1093/carcin/bgh231
© 2004 by Oxford University Press
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1 Vanderbilt University Medical Center, Suite 6000, MCE, Nashville, Tennessee 37232-8300
* To whom correspondence should be addressed. E-mail: Hiroki.Nagase{at}RoswellPark.org.
STK15 is considered a potential cancer susceptibility gene owing to its functions in normal cell mitosis. Two common coding-region polymorphisms in the gene (F31I, V57I) may affect ubiquitin-dependent degradation, and thus the half-life of the encoded protein. There are limited data on the relevance of these polymorphisms to population cancer rates. To examine whether functional variation in STK15 may affect breast cancer risk, we genotyped a large series of incident breast cancer cases (n=941) and age-matched population controls (n=830) for the F31I and V57I polymorphisms. Individually, neither the F31I polymorphism (odds ratio (OR): 1.54; 95% confidence interval (CI): 0.96-2.47, comparing 31I to 31F homozygotes) nor the V57I polymorphism (OR: 0.92; 95% CI: 0.50-1.71, comparing 57I to 57V homozygotes) was significantly associated with breast cancer risk. A relatively common genotype, combining the two polymorphisms (31I-57V/31I-57V; 3% of controls) was related to a significant 2-fold excess in the risk of postmenopausal breast cancer (odds ratio: 1.96; 95% confidence interval: 1.01-3.79). No interaction was detected between STK15 variants and estrogenic risk factors, though power in these analyses was limited. These results suggest that STK15 may represent a low penetrance type breast cancer susceptibility gene.
Revised June 24, 2004
Accepted July 6, 2004
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION
STK15 polymorphism and breast cancer risk in a population-based study
2 Cancer Prevention Research Group, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N. MP 900, Seattle, Washington 98104
3 Department of Epidemiology, Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Elm & Carlton Sts., Buffalo, New York 14263
4 Comprehensive Cancer Center and Department of Population Health Sciences, University of Wisconsin, WARF Room 701, 610 Walnut Street, Madison, Wisconsin 53726
5 Dartmouth Medical School, Norris Cotton Cancer Center, Lebanon, New Hampshire 03756
6 University of Wisconsin, WARF Room 307, 610 Walnut St, Madison, Wisconsin 53726
7 Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263
8 Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets Buffalo, New York 14263
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