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Carcinogenesis Advance Access published online on October 21, 2004
Carcinogenesis, doi:10.1093/carcin/bgh312
© 2004 by Oxford University Press
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Received April 13, 2004
Revised October 6, 2004
Accepted October 10, 2004

CANCER BIOLOGY

Role of a novel EGF-like domain containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells

Jian Ma 1, Jie Zhou 1, Songqing Fan 1, Lili Wang 1, Xiaoling Li 1, Qun Yan 2, Ming Zhou 1, Huaying Liu 1, Qiuhong Zhang 1, Houde Zhou 1, Kai Gan 1, Zheng Li 1, Cong Peng 1, Wei Xiong 1, Chen Tan 1, Shourong Shen 3, Jianbo Yang 1, Jiang Li 1, and Guiyuan Li 1*

1 Cancer Research Institute, Central South University Xiang-Ya School of Medicine, 110 Xiang-Ya Road, Changsha, Hunan, 410078, China
2 Xiang-Ya Hospital, Central South University Xiang-Ya School of Medicine, 110 Xiang-Ya Road, Changsha, Hunan, 410078, China
3 The Third Xiang-Ya Hospital, Central South University Xiang-Ya School of Medicine, 110 Xiang-Ya Road, Changsha, Hunan, 410078, China

* To whom correspondence should be addressed.
Guiyuan Li, E-mail: ligy{at}xysm.net


  Abstract

The EGF-like domain is involved in receptor-ligand interactions, extracellular matrix formation, cell adhesion and chemotaxis. NGX6 is a novel EGF-like domain containing gene located at the high frequent loss of heterozygosity (LOH) region 9p21-22 associated with nasopharyngeal carcinoma (NPC). It is down-regulated in NPC and its overexpression can delay the cell cycle G0-G1 progression in NPC cells. In the present study, in situ hybridization analysis, using NPC tissue microarrays, showed that loss of NGX6 expression was associated with NPC lymph node metastasis. The Tet-on gene expression system and cDNA array techniques were used to profile the potential targets of NGX6. We found that NGX6 can influence the expression of some cell adhesion molecules in NPC cells. NGX6 can associate with ezrin, a linkage between the cell membrane and cytoskeleton. The NGX6 protein was expressed on the cell surface as a glycoprotein. Ectopic induction of NGX6 can impair NPC cell migration and invasive ability as well as improve cell adhesion and gap junctional intercellular communication, and can suppress tumor formation in vivo. These data revealed that NGX6 plays a role in cell adhesion modulation in NPC cells.

Keywords: NGX6; EGF-like domain; nasopharyngeal carcinoma; cell adhesion.
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[Abstract] [Full Text] [PDF]


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