Carcinogenesis Advance Access published online on November 4, 2004
Carcinogenesis, doi:10.1093/carcin/bgh327
© 2004 by Oxford University Press
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Hebei Cancer Institute, Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
* To whom correspondence should be addressed. Matrix metalloproteinases (MMPs) are proteolytic enzymes that regulate various cell behaviors in cancer biology, via their basic function of degradation of proteins. Genetic variations in several MMP promoters may influence transcription and expression of MMPs. The aim of this study is to assess the effects of the two single nucleotide polymorphisms (SNPs), the guanine insertion polymorphism in the MMP1 promoter and the adenosine insertion polymorphism in the MMP3 promoter, on risk of the development and lymphatic metastasis of non-small cell lung carcinoma (NSCLC). The MMP1 and MMP3 SNPs were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 243 NSCLC patients and 350 control subjects in North China. The overall genotype and allelotype distribution of the both variants in cancer patients and controls was not significantly different (all P values are above 0.05). However, stratification analysis showed that, smoking individuals with the MMP3 5A allele had above 1.5-fold increased risk to develop NSCLC, compared with those harboring the 6A homozygous (the age and gender adjusted OR = 1.68, 95% CI = 1.04-2.70). In addition, the frequency of the MMP3 5A homozygote in NSCLC patients with lymphatic metastasis was significantly higher than that in lymph node negative ones (5.7% versus 0%, P = 0.04). Moreover, the MMP 1G/5A haplotype significantly increased the risk of lymphatic metastasis (OR = 3.36, 95% CI = 1.42-7.94), compared with the 2G/6A haplotype. The present result suggested that the MMP3 promoter polymorphism may modify susceptibility to NSCLC, and the MMP 1G/5A haplotype may predicate the risk of lymphatic metastasis of this tumor.
Revised October 20, 2004
Accepted October 26, 2004
CARCINOGENESIS
Polymorphisms in the MMP1 and MMP3 promoter and non-small cell lung carcinoma in North China
2 The Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Jianhui Zhang, E-mail: jianhuizh{at}hotmail.com
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Peng, L. Cao, W. Wang, L. Xian, D. Jiang, J. Zhao, Z. Zhang, X. Wang, and L. Yu Polymorphisms in the promoter regions of matrix metalloproteinases 1 and 3 and cancer risk: a meta-analysis of 50 case-control studies Mutagenesis, October 20, 2009; (2009) gep041v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Bradbury, R. Zhai, J. Hopkins, M. H. Kulke, R. S. Heist, S. Singh, W. Zhou, C. Ma, W. Xu, K. Asomaning, et al. Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis Carcinogenesis, May 1, 2009; 30(5): 793 - 798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Mercer, A. M. Wallace, C. E. Brinckerhoff, and J. M. D'Armiento Identification of a Cigarette Smoke-Responsive Region in the Distal MMP-1 Promoter Am. J. Respir. Cell Mol. Biol., January 1, 2009; 40(1): 4 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Sauter, A. Rosenberger, L. Beckmann, S. Kropp, K. Mittelstrass, M. Timofeeva, G. Wolke, A. Steinwachs, D. Scheiner, E. Meese, et al. Matrix Metalloproteinase 1 (MMP1) Is Associated with Early-Onset Lung Cancer Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1127 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Radisky and J. A. Przybylo Matrix Metalloproteinase-induced Fibrosis and Malignancy in Breast and Lung Proceedings of the ATS, April 15, 2008; 5(3): 316 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hughes, O. Agbaje, R. L. Bowen, D. L. Holliday, J. A. Shaw, S. Duffy, and J. L. Jones Matrix Metalloproteinase Single-Nucleotide Polymorphisms and Haplotypes Predict Breast Cancer Progression Clin. Cancer Res., November 15, 2007; 13(22): 6673 - 6680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sun, Y. Gao, W. Tan, S. Ma, X. Zhang, Y. Wang, Q. Zhang, Y. Guo, D. Zhao, C. Zeng, et al. Haplotypes in Matrix Metalloproteinase Gene Cluster on Chromosome 11q22 Contribute to the Risk of Lung Cancer Development and Progression Clin. Cancer Res., December 1, 2006; 12(23): 7009 - 7017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Heist, A. L. Marshall, G. Liu, W. Zhou, L. Su, D. Neuberg, T. J. Lynch, J. Wain, and D. C. Christiani Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer. Clin. Cancer Res., September 15, 2006; 12(18): 5448 - 5453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Su, W. Zhou, K. Asomaning, X. Lin, J. C. Wain, T. J. Lynch, G. Liu, and D. C. Christiani Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer Carcinogenesis, May 1, 2006; 27(5): 1024 - 1029. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Shan, Z. Lian-Fu, D. Hui, G. Wei, W. Na, J. Xia, and L. Yan Polymorphisms in the promoter regions of the matrix metalloproteinases-7, -9 and the risk of endometriosis and adenomyosis in China Mol. Hum. Reprod., January 1, 2006; 12(1): 35 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Schwartz and J. C. Ruckdeschel Familial Lung Cancer: Genetic Susceptibility and Relationship to Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., January 1, 2006; 173(1): 16 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Hu, X. Huo, D. Lu, J. Qian, J. Zhou, Y. Chen, L. Xu, H. Ma, J. Zhu, Q. Wei, et al. Functional Polymorphisms of Matrix Metalloproteinase-9 Are Associated with Risk of Occurrence and Metastasis of Lung Cancer Clin. Cancer Res., August 1, 2005; 11(15): 5433 - 5439. [Abstract] [Full Text] [PDF]
|
|