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Carcinogenesis Advance Access published online on February 24, 2005
Carcinogenesis, doi:10.1093/carcin/bgi034
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oupjournals.org
Received September 17, 2004
Revised January 6, 2005
Accepted January 24, 2005

CANCER BIOLOGY

Periostin induction in tumor cell line explants and inhibition of in-vitro cell growth by anti-periostin antibodies

Isabella T. Tai 1*, Meiru Dai 2, and Lan Bo Chen 2

1 Division of Gastroenterology, University of British Columbia, BC Cancer Agency, Vancouver, Canada; Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada
2 Department of Cancer Biology, Dana Farber Cancer Institute, Boston, USA

* To whom correspondence should be addressed.
Isabella T. Tai, E-mail: itai{at}bcgsc.ca


  Abstract

Several factors have been shown to promote growth of colorectal cancers. Here, we provide evidence that periostin, a protein with structural and sequence homology with a TGF-{beta}-inducible gene, {beta}ig-h3, is upregulated in colorectal cancers and their liver metastasis, and it may play a role in promoting growth in these tumors. In-vitro studies reveal that periostin promotes growth and cell proliferation in colorectal cancers and that this effect can be abrogated with antibodies to periostin. Furthermore, exposure of colorectal cancer cells to anti-periostin antibodies activates apoptosis and potentiates the effects of 5-fluorouracil chemotherapy. The results demonstrate growth promoting properties of periostin, and a possible role of targeting this protein as a therapeutic option in colorectal cancers.

Keywords: colorectal cancer; tumorigenesis; cell growth; apoptosis.
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