Carcinogenesis Advance Access published online on March 31, 2005
Carcinogenesis, doi:10.1093/carcin/bgi080
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1 USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
* To whom correspondence should be addressed. Experimental and epidemiological data have implicated a potential chemoprotective role of green tea polyphenols and a potential enhancing role of angiotensin II in the development of breast cancer in humans. Angiotensin II is converted from its precursor by angiotensin-converting enzyme (ACE). Women with the low-activity genotypes of the ACE gene had a reduced risk of breast cancer compared with those possessing the high-activity ACE genotypes. Experimental data showed that green tea polyphenols could inhibit angiotensin II-induced reactive oxygen species production. We reasoned that if this is one of the mechanisms by which green tea polyphenols protect against human breast cancer, then its effect should be more prominent among women possessing the high activity ACE genotype, than women with the low activity ACE genotype. In other words, we predict a stronger inverse green tea-breast cancer association among the former versus the latter subgroup of women. To test this hypothesis, we conducted a nested case-control study involving 297 incident breast cancer cases and 665 control subjects within the Singapore Chinese Health Study. There was no association between intake frequencies of green tea and risk of breast cancer among all women or those with low-activity ACE genotypes. Among women with the high-activity ACE genotypes, however, intake frequency of green tea was associated with a statistically significant decrease in risk of breast cancer (P for trend = 0.039); the odds ratio (95% confidence interval) was 0.33 (0.13-0.82) for women drinking green tea at least monthly and 0.29 (0.10-0.79) for those drinking green tea at least weekly compared with non-drinkers. There was a statistically significant interaction effect between green tea intake and ACE genotype on risk of breast cancer (P for interaction = 0.01). Black tea intake was unrelated to breast cancer risk irrespective of the ACE genotype. The findings of the present study highlight the importance of genetically determined factors in evaluating the role of green tea intake in the development of breast cancer.
Received January 5, 2005
Revised March 12, 2005
Accepted March 22, 2005
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION
Green tea intake, ACE gene polymorphism and breast cancer risk among Chinese women in Singapore
2 Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
3 Cancer Center, University of Minnesota, Minneapolis, MN55455, USA
Jian-Min Yuan, E-mail: jyuan{at}usc.edu
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