Carcinogenesis Advance Access published online on June 1, 2005
Carcinogenesis, doi:10.1093/carcin/bgi144
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Hebei Cancer Institute, Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
* To whom correspondence should be addressed. An A to G transition at the 181 base pair position upstream of the transcription initiation site of the matrix metalloproteinase-7 (MMP-7) gene (-181A/G) may modify the development and progression of some diseases via influencing the transcription activity of the promoter. To assess the effects of the functional single nucleotide polymorphism (SNP) on cancer susceptibility and progression, the MMP-7 -181 A/G genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis among 258 patients with esophageal squamous cell carcinoma (ESCC), 201 patients with gastric cardiac carcinoma (GCA), 243 patients with non-small cell lung carcinoma (NSCLC), and 350 healthy individuals without cancer. The result showed that the frequency of the -181G allele in ESCC, GCA and NSCLC patients was significantly higher than that in healthy controls (P = 0.019, 0.023 and 0.004, respectively). Compared to the A/A genotype, genotypes with the -181G allele (A/G +G/G) significantly increased susceptibility to all three tumors, with adjusted odds ratio of 1.83 (95% CI = 1.12-2.99) for ESCC, 1.96 (95% CI = 1.17-3.29) for GCA and 2.00 (95% CI = 1.23-3.24) for NSCLC, respectively. Stratification analysis showed that smoking did not significantly influence the association between the MMP-7 -181A/G and GCA or NSCLC, while the -181G allele only significantly increased susceptibility to ESCC among smokers. In addition, association between the -181G allele and susceptibility to ESCC and GCA showed only significant among individuals with family history of upper gastrointestinal cancer. The correlation of the MMP-7 -181A/G polymorphism with potential of lymphatic metastasis was not observed in all three tumors. The study suggested that, the MMP-7 -181A/G polymorphism might be a candidate marker for predicating individuals who are at higher risk to certain tumors but might not be used to predicate potential of lymphatic metastasis in ESCC, GCA and NSCLC.
Received January 9, 2005
Revised May 17, 2005
Accepted May 24, 2005
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION
The functional polymorphism in the matrix metalloproteinase-7 promoter increases susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma
2 The Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Jianhui Zhang, E-mail: Jianhuizh{at}hotmail.com
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Zhang, J.-Z. Di, Z.-Z. Zhu, H.-M. Wu, Y. Wang, G. Zhu, Q. Zheng, and L. Hou Association of Transforming Growth Factor-beta 1 Polymorphisms with Genetic Susceptibility to TNM Stage I or II Gastric Cancer Jpn. J. Clin. Oncol., December 1, 2008; 38(12): 861 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Qiu, G. Zhou, Y. Zhai, X. Zhang, W. Xie, H. Zhang, H. Yang, L. Zhi, X. Yuan, X. Zhang, et al. No Association of MMP-7, MMP-8, and MMP-21 Polymorphisms with the Risk of Hepatocellular Carcinoma in a Chinese Population Cancer Epidemiol. Biomarkers Prev., September 1, 2008; 17(9): 2514 - 2518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Beeghly-Fadiel, J.-R. Long, Y.-T. Gao, C. Li, S. Qu, Q. Cai, Y. Zheng, Z.-X. Ruan, S. E. Levy, S. L. Deming, et al. Common MMP-7 Polymorphisms and Breast Cancer Susceptibility: A Multistage Study of Association and Functionality Cancer Res., August 1, 2008; 68(15): 6453 - 6459. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-X. Zhang, C. Zhang, Y. H. Shen, J. Wang, X. N. Li, Y. Zhang, J. Coselli, and X. L. Wang Biogenesis of Short Intronic Repeat 27-Nucleotide Small RNA from Endothelial Nitric-oxide Synthase Gene J. Biol. Chem., May 23, 2008; 283(21): 14685 - 14693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hughes, O. Agbaje, R. L. Bowen, D. L. Holliday, J. A. Shaw, S. Duffy, and J. L. Jones Matrix Metalloproteinase Single-Nucleotide Polymorphisms and Haplotypes Predict Breast Cancer Progression Clin. Cancer Res., November 15, 2007; 13(22): 6673 - 6680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sun, Y. Gao, W. Tan, S. Ma, X. Zhang, Y. Wang, Q. Zhang, Y. Guo, D. Zhao, C. Zeng, et al. Haplotypes in Matrix Metalloproteinase Gene Cluster on Chromosome 11q22 Contribute to the Risk of Lung Cancer Development and Progression Clin. Cancer Res., December 1, 2006; 12(23): 7009 - 7017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-A. Yoon, B. Hwangbo, I.-J. Kim, S. Park, H. S. Kim, H. J. Kee, J. E. Lee, Y. K. Jang, J.-G. Park, and J. S. Lee Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer Carcinogenesis, November 1, 2006; 27(11): 2217 - 2222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ii, H. Yamamoto, Y. Adachi, Y. Maruyama, and Y. Shinomura Role of Matrix Metalloproteinase-7 (Matrilysin) in Human Cancer Invasion, Apoptosis, Growth, and Angiogenesis Experimental Biology and Medicine, January 1, 2006; 231(1): 20 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Shan, Z. Lian-Fu, D. Hui, G. Wei, W. Na, J. Xia, and L. Yan Polymorphisms in the promoter regions of the matrix metalloproteinases-7, -9 and the risk of endometriosis and adenomyosis in China Mol. Hum. Reprod., January 1, 2006; 12(1): 35 - 39. [Abstract] [Full Text] [PDF]
|
|