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Carcinogenesis Advance Access first published online on June 1, 2005
This version published online on November 17, 2005
Carcinogenesis, doi:10.1093/carcin/bgi147
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org
Received March 4, 2005
Revised May 13, 2005
Accepted May 29, 2005

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION

Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine

Haitao Luo 1, Lili Tang 1, Meng Tang 1, Madhavi Billam 1, Tianren Huang 2, Jiahua Yu 3, Zhongliang Wei 4, Yongqiang Liang 4, Kaibo Wang 4, Zhen-Quan Zhang 3, Lisheng Zhang 3, and Jia-Sheng Wang 1 *

1 The Institute of Environmental and Human Health and Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas
2 The Institute of Environmental and Human Health and Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas; Guangxi Cancer Institute, Nanning, Guangxi, China
3 Guangxi Cancer Institute, Nanning, Guangxi, China
4 Fusui Liver Cancer Institute, Fusui, Guangxi, China

* To whom correspondence should be addressed.
Jia-Sheng Wang, E-mail: js.wang{at}ttu.edu


  Abstract

Modulation of urinary excretion of green tea polyphenols (GTP) and oxidative DNA damage biomarker, 8-hydroxydeoxyguanosine (8-OHdG), was assessed in urine samples collected from a randomized, double blinded, and placebo controlled phase IIa chemoprevention trial with GTP in 124 individuals. These individuals were sero-positive for both HBsAg and aflatoxin-albumin adducts, and took GTP capsules daily at doses of 500-mg, 1,000-mg or a placebo for 3 months. Twenty-four hour urine samples were collected before the intervention and at the first and third month of the study. Urinary excretion of 8-OHdG and GTP components was measured by HPLC-CoulArray electrochemical detection. The baseline levels of 8-OHdG and GTP components among the three groups showed homogeneity (p>0.70), and a non-significant fluctuation was observed in the placebo group over the 3 months (p>0.30). In GTP treated groups, epigallocatechin (EGC) and epicatechin (EC) levels displayed significant and dose-dependent increases in both the 500-mg group and 1000-mg group (p<0.05). The 8-OHdG levels did not differ between the three groups at the 1-month collection, with medians of 1.83, 2.08, and 1.86 ng/mg-creatinine for placebo, 500-mg, and 1000-mg group, respectively (p=0.999). At the end of the 3 months' intervention, 8-OHdG levels decreased significantly in both GTP treated groups, with medians of 2.02, 1.03, and 1.15 ng/mg-creatinine for placebo, 500-mg, and 1000-mg group, respectively (p=0.007). These results suggest that urinary excretions of EGC and EC can serve as practical biomarkers for green tea consumption in human populations. The results also suggest that chemoprevention with GTP is effective in diminishing oxidative DNA damage.

Clyde Martin and Shan Sun have requested that their names be removed as authors of this paper.


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