Carcinogenesis Advance Access published online on June 1, 2005
Carcinogenesis, doi:10.1093/carcin/bgi148
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1 The Cancer Center, University of Minnesota, Minneapolis, MN 55455
* To whom correspondence should be addressed. A new study demonstrates that lifetime whole body exposure of B6C3F1 mice to high doses of cigarette smoke robustly increases lung cancer incidence compared to sham exposed animals. This is the first study to demonstrate a strong effect of inhaled cigarette smoke on lung cancer in an animal model. This commentary attempts to put the new results in perspective with the existing literature on cigarette smoke inhalation studies in animals and discusses strengths, limitations, and possible applications of available models.
Received May 17, 2005
Accepted May 29, 2005
COMMENTARY
Carcinogenicity studies of inhaled cigarette smoke in laboratory animals: old and new
Stephen S. Hecht, E-mail: hecht002{at}umn.edu
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