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Carcinogenesis Advance Access published online on June 1, 2005
Carcinogenesis, doi:10.1093/carcin/bgi148
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oupjournals.org
Received May 17, 2005
Accepted May 29, 2005

COMMENTARY

Carcinogenicity studies of inhaled cigarette smoke in laboratory animals: old and new

Stephen S. Hecht 1*

1 The Cancer Center, University of Minnesota, Minneapolis, MN 55455

* To whom correspondence should be addressed.
Stephen S. Hecht, E-mail: hecht002{at}umn.edu


  Abstract

A new study demonstrates that lifetime whole body exposure of B6C3F1 mice to high doses of cigarette smoke robustly increases lung cancer incidence compared to sham exposed animals. This is the first study to demonstrate a strong effect of inhaled cigarette smoke on lung cancer in an animal model. This commentary attempts to put the new results in perspective with the existing literature on cigarette smoke inhalation studies in animals and discusses strengths, limitations, and possible applications of available models.


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