Skip Navigation



Carcinogenesis Advance Access published online on September 29, 2005
Carcinogenesis, doi:10.1093/carcin/bgi232
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
27/3/560    most recent
bgi232v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Zienolddiny, S.
Right arrow Articles by Haugen, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zienolddiny, S.
Right arrow Articles by Haugen, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oupjournals.org
Received June 29, 2005
Revised September 20, 2005
Accepted September 20, 2005

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION

Polymorphisms of DNA repair genes and risk of non-small cell lung cancer

Shanbeh Zienolddiny 1 {dagger}, Daniele Campa 2 {dagger}, Helge Lind 1, David Ryberg 1, Vidar Skaug 1, Lodve Stangeland 3, David H. Phillips 4, Federico Canzian 5, and Aage Haugen 1*

1 Department of Toxicology, National Institute of Occupational Health, Oslo, Norway
2 Genome Analysis Group, International Agency for Research on Cancer, Lyon, France; Department of Science for the study of Man and Environment, University of Pisa, Pisa, Italy
3 Haukeland University Hospital, Bergen, Norway
4 Section of Molecular Carcinogenesis, Institute of Cancer Research, Cotswold Road, Surrey SM2 5NG, United Kingdom
5 Genome Analysis Group, International Agency for Research on Cancer, Lyon, France

* To whom correspondence should be addressed.
Aage Haugen, E-mail: age.haugen{at}stami.no


  Abstract

Lung cancer is a leading cause of cancer mortality with an interindividual difference in susceptibility to the disease. The inheritance of low-efficiency genotypes involved in DNA repair and replication may contribute to the difference in susceptibility. We investigated 44 single nucleotide polymorphisms (SNPs) in 20 DNA repair genes including nucleotide excision repair (NER) genes XPA, ERCC1, ERCC2/XPD, ERCC4/XPF, ERCC5/XPG; base excision repair (BER) genes APE1/APEX, OGG1, MPG, XRCC1, PCNA, POLB, POLi, LIG3, EXO1; double strand break repair (DSB-R) genes XRCC2, XRCC3, XRCC9, NBS1, ATR, and direct damage reversal (DR) gene MGMT/AGT. The study included 343 non-small cell lung cancer (NSCLC) cases and 413 controls from Norwegian general population. Our results indicate that SNPs in the NER genes ERCC1 (Asn118Asn, 15310G>C, 8902G>T), XPA (-4G>A), ERCC2/XPD (Lys751Gln), ERCC5/XPD (His46His), the BER genes APE1/APEX (Ile64Val), OGG1 (Ser326Cys), PCNA (1876A>G), XRCC1 (Arg194Trp, Arg280His, Arg399Gln); the DSB-R genes ATR (Thr211Met), NBS1 (Glu185Gln), XRCC2 (Arg188His), XRCC9 (Thr297Ile) genes modulate NSCLC risk. The level of polycyclic aromatic hydrocarbon DNA adducts (PAH-DNA) in normal lung tissue from 211 patients was analyzed. The variant alleles of XRCC1(Arg280His), XRCC1 (Arg399Gln), ERCC1(G8092T), ERCC5(His46His) and MGMT/AGT(Lys178Arg) were more frequent in patients with PAH-DNA adduct levels lower than the mean whereas the XRCC1(Arg194Trp) variant was more frequent in cases with higher adduct levels than the mean.

Keywords: Lung cancer; polymorphism; SNP; DNA repair.

{dagger} These authors contributed equally to the manuscript


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 MutagenesisHome page
Y. Zhong, Y. Huang, Y. Huang, T. Zhang, C. Ma, S. Zhang, W. Fan, H. Chen, J. Qian, and D. Lu
Effects of O6-methylguanine-DNA methyltransferase (MGMT) polymorphisms on cancer: a meta-analysis
Mutagenesis, November 5, 2009; (2009) gep050v1.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
D. Gu, M. Wang, M. Wang, Z. Zhang, and J. Chen
The DNA repair gene APE1 T1349G polymorphism and cancer risk: a meta-analysis of 27 case-control studies
Mutagenesis, November 1, 2009; 24(6): 507 - 512.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J. Lu, S. Zhang, D. Chen, H. Wang, W. Wu, X. Wang, Y. Lei, J. Wang, J. Qian, W. Fan, et al.
Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility
FASEB J, October 1, 2009; 23(10): 3459 - 3469.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. R. Gandara, T. Kawaguchi, J. Crowley, J. Moon, K. Furuse, M. Kawahara, S. Teramukai, Y. Ohe, K. Kubota, S. K. Williamson, et al.
Japanese-US Common-Arm Analysis of Paclitaxel Plus Carboplatin in Advanced Non-Small-Cell Lung Cancer: A Model for Assessing Population-Related Pharmacogenomics
J. Clin. Oncol., July 20, 2009; 27(21): 3540 - 3546.
[Abstract] [Full Text] [PDF]

Home page
 Anticancer ResHome page
B. AGACHAN, O. KUCUKHUSEYIN, P. AKSOY, A. TURNA, I. YAYLIM, U. GORMUS, A. ERGEN, U. ZEYBEK, B. DALAN, and T. ISBIR
Apurinic/Apyrimidinic Endonuclease (APE1) Gene Polymorphisms and Lung Cancer Risk in Relation To Tobacco Smoking
Anticancer Res, June 1, 2009; 29(6): 2417 - 2420.
[Abstract] [Full Text] [PDF]

Home page
 Acta Biochim Biophys SinHome page
J. Feng, X. Sun, N. Sun, S. Qin, F. Li, H. Cheng, B. Chen, Y. Cao, J. Ma, L. Cheng, et al.
XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer
Acta Biochim Biophys Sin, May 1, 2009; 41(5): 429 - 435.
[Abstract] [Full Text] [PDF]

Home page
 Anticancer ResHome page
N.-Y. HSU, H.-C. WANG, C.-H. WANG, C.-F. CHIU, H.-C. TSENG, S.-Y. LIANG, C.-W. TSAI, C.-C. LIN, and D.-T. BAU
Lung Cancer Susceptibility and Genetic Polymorphisms of Exo1 Gene in Taiwan
Anticancer Res, February 1, 2009; 29(2): 725 - 730.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. Li, H. Suzuki, B. Liu, J. Morris, J. Liu, T. Okazaki, Y. Li, P. Chang, and J. L. Abbruzzese
DNA Repair Gene Polymorphisms and Risk of Pancreatic Cancer
Clin. Cancer Res., January 15, 2009; 15(2): 740 - 746.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
Y.-L. Lo, Y.-S. Jou, C.-F. Hsiao, G.-C. Chang, Y.-H. Tsai, W.-C. Su, K.-Y. Chen, Y.-M. Chen, M.-S. Huang, C. Y. Hu, et al.
A Polymorphism in the APE1 Gene Promoter is Associated with Lung Cancer Risk
Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 223 - 229.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
H. Li, X. Hao, W. Zhang, Q. Wei, and K. Chen
The hOGG1 Ser326Cys Polymorphism and Lung Cancer Risk: A Meta-analysis
Cancer Epidemiol. Biomarkers Prev., July 1, 2008; 17(7): 1739 - 1745.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Zienolddiny, D. Campa, H. Lind, D. Ryberg, V. Skaug, L. B. Stangeland, F. Canzian, and A. Haugen
A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers
Carcinogenesis, June 1, 2008; 29(6): 1164 - 1169.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Z. Hu, H. Liu, H. Wang, R. Miao, W. Sun, G. Jin, Y. Wang, H. Ma, L. Jin, Q. Wei, et al.
Tagging Single Nucleotide Polymorphisms in Phosphoinositide-3-Kinase-Related Protein Kinase Genes Involved in DNA Damage "Checkpoints" and Lung Cancer Susceptibility
Clin. Cancer Res., May 1, 2008; 14(9): 2887 - 2891.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Okazaki, L. Jiao, P. Chang, D. B. Evans, J. L. Abbruzzese, and D. Li
Single-Nucleotide Polymorphisms of DNA Damage Response Genes Are Associated with Overall Survival in Patients with Pancreatic Cancer
Clin. Cancer Res., April 1, 2008; 14(7): 2042 - 2048.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
E.L. Crawford, T. Blomquist, D.N. Mullins, Y. Yoon, D.R. Hernandez, M. Al-Bagdhadi, J. Ruiz, J. Hammersley, and J.C. Willey
CEBPG regulates ERCC5/XPG expression in human bronchial epithelial cells and this regulation is modified by E2F1/YY1 interactions
Carcinogenesis, December 1, 2007; 28(12): 2552 - 2559.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I. P. Gorlov, P. Meyer, T. Liloglou, J. Myles, M. B. Boettger, A. Cassidy, L. Girard, J. D. Minna, R. Fischer, S. Duffy, et al.
Seizure 6-Like (SEZ6L) Gene and Risk for Lung Cancer
Cancer Res., September 1, 2007; 67(17): 8406 - 8411.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J. An, Z. Liu, Z. Hu, G. Li, L.-E Wang, E. M. Sturgis, A. K. El-Naggar, M. R. Spitz, and Q. Wei
Potentially Functional Single Nucleotide Polymorphisms in the Core Nucleotide Excision Repair Genes and Risk of Squamous Cell Carcinoma of the Head and Neck
Cancer Epidemiol. Biomarkers Prev., August 1, 2007; 16(8): 1633 - 1638.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
N. Gungor, R. W.L. Godschalk, D. M. Pachen, F. J. Van Schooten, and A. M. Knaapen
Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase
FASEB J, August 1, 2007; 21(10): 2359 - 2367.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
C. V. Breton, W. Zhou, M. L. Kile, E.A. Houseman, Q. Quamruzzaman, M. Rahman, G. Mahiuddin, and D. C. Christiani
Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes
Carcinogenesis, July 1, 2007; 28(7): 1520 - 1525.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. Hall, M. Hashibe, P. Boffetta, V. Gaborieau, N. Moullan, A. Chabrier, D. Zaridze, O. Shangina, N. Szeszenia-Dabrowska, D. Mates, et al.
The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract
Carcinogenesis, March 1, 2007; 28(3): 665 - 671.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. G. Schwartz, G. M. Prysak, C. H. Bock, and M. L. Cote
The molecular epidemiology of lung cancer
Carcinogenesis, March 1, 2007; 28(3): 507 - 518.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
L. Wang, H. Liu, Z. Zhang, M. R. Spitz, and Q. Wei
Association of Genetic Variants of O6-Methylguanine-DNA Methyltransferase with Risk of Lung Cancer in Non-Hispanic Whites
Cancer Epidemiol. Biomarkers Prev., December 1, 2006; 15(12): 2364 - 2369.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. Lu, Q. Wei, M. L. Bondy, D. Li, A. Brewster, S. Shete, T.-K. Yu, A. Sahin, F. Meric-Bernstam, K. K. Hunt, et al.
Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <=55 years
Carcinogenesis, November 1, 2006; 27(11): 2209 - 2216.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. W. Hill and M. K. Evans
Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase
Nucleic Acids Res., March 20, 2006; 34(5): 1620 - 1632.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.