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Carcinogenesis Advance Access published online on October 11, 2005
Carcinogenesis, doi:10.1093/carcin/bgi243
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org
Received August 1, 2005
Revised September 11, 2005
Accepted October 4, 2005

REVIEW

Emerging role of KLF4 in human gastrointestinal cancer

Daoyan Wei 1, Masashi Kanai 1, Suyun Huang 2, and Keping Xie 3*

1 Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
2 Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA; Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
3 Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA; Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA

* To whom correspondence should be addressed.
Keping Xie, E-mail: kepxie{at}mail.mdanderson.org


  Abstract

Recent analyses revealed that Krüppel-like factors (KLFs) play important roles in both normal development and carcinogenesis. Of the 16 known KLFs, KLF4 has been shown to be involved in regulation of proliferation, differentiation, and tumorigenesis of gastrointestinal tract epithelium. Clinical, experimental, and mechanistic findings indicate that KLF4 is a bona fide tumor suppressor for both gastric and colorectal cancers. In this review, we summarize how this growing area of research has formed and the challenging new frontiers for better understanding of the oncogenic potential of the KLFs.


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