Skip Navigation



Carcinogenesis Advance Access published online on November 14, 2005
Carcinogenesis, doi:10.1093/carcin/bgi267
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
27/4/820    most recent
bgi267v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ravn-Haren, G.
Right arrow Articles by Vogel, U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ravn-Haren, G.
Right arrow Articles by Vogel, U.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org
Received June 27, 2005
Revised September 5, 2005
Accepted November 9, 2005

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION

Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study

Gitte Ravn-Haren 1 *, Anja Olsen 2, Anne Tjønneland 2, Lars O. Dragsted 1, Bjørn A. Nexø 3, Håkan Wallin 4, Kim Overvad 5, Ole Raaschou-Nielsen 2, and Ulla Vogel 4

1 Department of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research, Søborg, Denmark
2 Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
3 Institute of Human Genetics, University of Aarhus, Aarhus, Denmark
4 National Institute of Occupational Health, Copenhagen, Denmark
5 Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

* To whom correspondence should be addressed.
Gitte Ravn-Haren, E-mail: grh{at}dfvf.dk


  Abstract

Breast cancer may be related to oxidative stress. Breast cancer patients have been reported to have lower antioxidant enzyme activity than healthy controls, and the polymorphism GPX1 Pro198Leu has been associated with risk of lung and breast cancer. The purpose of the present nested case-control study was to determine whether GPX1 Pro198Leu and glutathione peroxidase (GPX) activity in prospectively collected blood samples are associated with breast cancer risk among postmenopausal women and whether GPX activity levels are associated with other known breast cancer risk factors. We matched 377 female breast cancer cases with 377 controls all nested within the prospective "Diet, Cancer and Health" study of 57000 Danes. Carriers of the variant T-allele of GPX1 Pro198Leu were at 1.43-fold higher risk of breast cancer compared with non-carriers (95% CI=1.07-1.92). Pre-diagnostic GPX activity tended to be lower in cases compared to controls. GPX activity was positively correlated with intake of alcohol (P<0.0001) and the catalytic activity was lowered 5% for each additional copy of the variant T-allele (P=0.0003). Alcohol intake was correlated with increased GPX activity for the C-allele but not for the T-allele. Results from this prospective study suggest, that the GPX1 Pro198Leu-associated lowered GPX activity is associated with higher breast cancer risk among Danish women.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Res.Home page
P. Zhuo, M. Goldberg, L. Herman, B.-S. Lee, H. Wang, R. L. Brown, C. B. Foster, U. Peters, and A. M. Diamond
Molecular Consequences of Genetic Variations in the Glutathione Peroxidase 1 Selenoenzyme
Cancer Res., October 15, 2009; 69(20): 8183 - 8190.
[Abstract] [Full Text] [PDF]

Home page
 Neuro Oncol DukeHome page
P. Rajaraman, A. Hutchinson, N. Rothman, P. M. Black, H. A. Fine, J. S. Loeffler, R. G. Selker, W. R. Shapiro, M. S. Linet, and P. D. Inskip
Oxidative response gene polymorphisms and risk of adult brain tumors
Neuro-oncol, January 1, 2008; 10(5): 709 - 715.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
C.-C. Hong, C. B. Ambrosone, J. Ahn, J.-Y. Choi, M. L. McCullough, V. L. Stevens, C. Rodriguez, M. J. Thun, and E. E. Calle
Genetic Variability in Iron-Related Oxidative Stress Pathways (Nrf2, NQ01, NOS3, and HO-1), Iron Intake, and Risk of Postmenopausal Breast Cancer
Cancer Epidemiol. Biomarkers Prev., September 1, 2007; 16(9): 1784 - 1794.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
J.-Y. Choi, M. L. Neuhouser, M. Barnett, M. Hudson, A. R. Kristal, M. Thornquist, I. B. King, G. E. Goodman, and C. B. Ambrosone
Polymorphisms in Oxidative Stress-Related Genes Are Not Associated with Prostate Cancer Risk in Heavy Smokers
Cancer Epidemiol. Biomarkers Prev., June 1, 2007; 16(6): 1115 - 1120.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Walshe, M. M. Serewko-Auret, N. Teakle, S. Cameron, K. Minto, L. Smith, P. C. Burcham, T. Russell, G. Strutton, A. Griffin, et al.
Inactivation of Glutathione Peroxidase Activity Contributes to UV-Induced Squamous Cell Carcinoma Formation
Cancer Res., May 15, 2007; 67(10): 4751 - 4758.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
C. B. Ambrosone, P. G. Shields, J. L. Freudenheim, and C.-C. Hong
Re: Commonly Studied Single-Nucleotide Polymorphisms and Breast Cancer: Results From the Breast Cancer Association Consortium
J Natl Cancer Inst, March 21, 2007; 99(6): 487 - 487.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
P. Pharoah
Response: Re: Commonly Studied Single-Nucleotide Polymorphisms and Breast Cancer: Results From the Breast Cancer Association Consortium
J Natl Cancer Inst, March 21, 2007; 99(6): 488 - 489.
[Full Text] [PDF]

Home page
 CarcinogenesisHome page
U. Vogel, J. Christensen, B. A Nexo, H. Wallin, S. Friis, and A. Tjonneland
Peroxisome profilerator-activated receptor{gamma}2 Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes
Carcinogenesis, February 1, 2007; 28(2): 427 - 434.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.