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Carcinogenesis Advance Access published online on November 14, 2005
Carcinogenesis, doi:10.1093/carcin/bgi271
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org
Received August 30, 2005
Revised November 6, 2005
Accepted November 9, 2005

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION

The preventive effect of salvianolic acid B on malignant transformation of DMBA-induced oral premalignant lesion in hamsters

Zeng-Tong Zhou 1 *, Ya Yang 1, and Jian-Ping Ge 2

1 Department of Oral Medicine, Affiliated Ninth People's Hospital, School of Stomatology, Shanghai Jiaotong University, Shanghai Institute of Stomatology, 639 Zhizao Ju Road, Shanghai, 200011, China
2 Department of Oral Medicine, Tongji Hospital of Stomatology, Tongji University, 399 Yanchang Road, Shanghai, 200072, China

* To whom correspondence should be addressed.
Zeng-Tong Zhou, E-mail: Julieyy{at}163.com


  Abstract

Salvia miltiorrhiza (SM) has been used clinically in Asian countries to improve the microcirculation in the human body. Salvianolic acid B (Sal B), a pure compound extracted from SM, has been reported to be effective against fibrosis and ischemia-reperfusion injury, possibly through its anti-lipid peroxidation action. But the effect of Sal B on oral premalignant lesion and oral carcinogenesis remains unexplored. It is our interest to investigate the chemopreventive effect of Sal B on 7,12 dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters with respect to angiogenesis. 70 male Syrian golden hamsters were randomly divided into 5 groups, with two of 20 and three of 10. DMBA solution (0.5% in acetone) was applied topically to the left cheek pouch of male Syrian golden hamsters in group A and B, while animals in group C were painted with acetone, 3 times a week for 6 weeks. For the next 18 weeks, animals in group B and D received Sal B daily (10mg/kg BW/d) by gavage, animals in group A and C received same volume of saline. Animals in group E received no treatment and served as blank control. At the end of the experiment, animals were sacrificed and tissue samples were collected for histopathological and immunohistochemical examinations. The results showed that Sal B significantly decreased the squamous cell carcinoma (SCC) incidence from 64.7% (11/17) to16.7% (3/18)(p=0.004); angiogenesis was inhibited in dysplasia and SCC (p<0.01),with a simultaneous decrease in the immunostaining of HIF-1{alpha} and VEGF protein(p<0.05). The results suggested that Sal B had inhibitory effect against the malignant transformation of oral precancerous lesion and such inhibition may be related to the inhibition of angiogenesis.


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