Carcinogenesis Advance Access published online on December 12, 2005
Carcinogenesis, doi:10.1093/carcin/bgi309
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1 Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore; Centre for Molecular Epidemiology, National University of Singapore, Singapore
* To whom correspondence should be addressed. Recent evidence suggests that inflammatory pathways are important mediators of carcinogenesis. Asthma, allergic rhinitis and atopic dermatitis are clinical manifestations of a systemic atopic disorder, which is associated with airway hyper-responsiveness and inflammation. We examined the effect of a history of asthma/atopy among 132 lung cancer cases (of which 72% were adenocarcinomas) and 163 controls, all of whom were non-smoking Chinese women, in combination with a single nucleotide polymorphism (-634C/G) in the interleukin-6 (IL-6) gene which regulates secretion of a pro-inflammatory cytokine found to be predominant in lung tumour tissue. We observed a slight increase in risk of lung cancer (OR 1.5, 95% CI 0.8-2.6) and of adenocarcinoma (OR 1.6, 0.9-3.1) with asthma/atopy alone. There was no effect of the IL-6 CG/GG genotype on lung cancer risk on its own. Among individuals with both asthma/atopy and the IL6 -634 G allele, however, risk was increased at least threefold (OR 3.1, 1.2-8.3 for all cancers and OR 4.2, 1.5-11.6 for adenocarcinomas) relative to individuals with no asthma/atopy and the CC genotype. On stratified analysis, a significant increase in risk with asthma/atopy was restricted to those with the at-risk genotype (pint<0.05). Our findings are consistent with the role of chronic inflammation as an aetiologic factor among non-smoking Asian women, and suggest that asthma/atopy is a risk marker for susceptibility to the development of lung cancer.
Received September 23, 2005
Revised October 30, 2005
Accepted December 6, 2005
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION
Joint effect of asthma/atopy and an IL-6 gene polymorphism on lung cancer risk among lifetime non-smoking Chinese women
Adeline Seow 1 *,
Daniel P. K. Ng 1,
Serena Choo 2,
Philip Eng 3,
Wee-Teng Poh 4,
Teh Ming 5,
and
Yee-Tang Wang 6
2 Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
3 Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore
4 Laboratory Medicine, Changi General Hospital, Singapore
5 Department of Pathology, National University of Singapore, Singapore
6 Respiratory Medicine, Tan Tock Seng Hospital, Singapore
Adeline Seow, E-mail: cofseowa{at}nus.edu.sg
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