Carcinogenesis Advance Access published online on February 25, 2006
Carcinogenesis, doi:10.1093/carcin/bgi381
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1 Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
* To whom correspondence should be addressed. In addition to environmental exposures like UV radiation and, in some cases, arsenic contamination of drinking water, genetic factors may also influence the individual susceptibility to basal cell carcinoma of skin (BCC). In the present study, 529 cases diagnosed with BCC and 533 controls from Hungary, Romania and Slovakia were genotyped for one polymorphism in each of seven DNA repair genes. The variant allele for T241M (C>T) polymorphism in the XRCC3 gene was associated with a decreased cancer risk (OR 0.73, 95% CI 0.61-0.88, P 0.0007, multiple testing corrected P 0.004). The risk of multiple BCC was significantly lower among variant allele carriers than in non-carriers (P 0.04). Men homozygous for the C-allele for E185Q (G>C) polymorphism in the NBS1 gene showed an increased BCC risk (OR 2.19, 95%CI 1.23-3.91), but not women (OR 0.84 95%CI 0.49-1.47). In men, the age and nationality adjusted OR for the genotype CC (XRCC3)/CC (NBS1) was 8.79 (95% CI 2.10-36.8), compared to the genotype TT (XRCC3)/GG (NBS1). The data from this study show overall risk modulation of BCC by variant allele for T241M polymorphism in XRCC3 and gender-specific effect by E185Q polymorphism in NBS1.
Received October 19, 2005
Revised February 7, 2006
Accepted February 19, 2006
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION
Single nucleotide polymorphisms in DNA repair genes and basal cell carcinoma of skin
Ranjit Kumar Thirumaran 1 *,
Justo Lorenzo Bermejo 1 *,
Peter Rudnai 2,
Eugene Gurzau 3,
Kvetoslava Koppova 4,
Walter Goessler 5,
Marie Vahter 6,
Giovanni S. Leonardi 7,
Felicity Clemens 7,
Tony Fletcher 7,
Kari Hemminki 8,
and
Rajiv Kumar 8 *
2 National Institute of Enivironmental Health, Budapest, Hungary
3 Environmental Health Center, Cluj, Romania
4 State Health Institute, Banska Bystrica, Slovakia
5 Institute for Chemistry, Karl-Franzens University, Graz, Austria
6 Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
7 London School of Hygiene and Tropical Medicine, London, UK
8 Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany; Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
Rajiv Kumar, E-mail: r.kumar{at}dkfz.de
Abstract
*Both have contributed equally.
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