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Carcinogenesis Advance Access first published online on April 10, 2006
This version published online on April 25, 2006
Carcinogenesis, doi:10.1093/carcin/bgl035
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org
Received February 2, 2006
Accepted March 29, 2006

CANCER BIOLOGY

Carcinogenesis and apoptosis: paradigms and paradoxes

Boris Zhivotovsky 1 * and Sten Orrenius 1

1 Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden

* To whom correspondence should be addressed.
Boris Zhivotovsky, E-mail: boris.zhivotovsky{at}ki.se


  Abstract

Apoptosis is a physiological process of cell elimination, which is important for both maintenance of cellular homeostasis and cell proliferation and differentiation. Disturbances in the cell death process might lead to uncontrolled cell growth and to tumor formation. In addition, proper function of the apoptotic machinery is critical for tumor susceptibility to treatment. Many pro- and anti-apoptotic genes have been cloned and their significance for proper function of the apoptotic pathways carefully investigated. However, the precise role of these genes and their products in cancer development is less clear. Here, we will discuss some of the current paradigms and paradoxes concerning the involvement of apoptotic genes in carcinogenesis.

Keywords: Cancer; apoptosis; tumor suppressor; oncogene; caspase; Bcl-2.
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