Carcinogenesis Advance Access published online on April 25, 2006
Carcinogenesis, doi:10.1093/carcin/bgl048
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030
* To whom correspondence should be addressed. Background: Deregulation of cell cycle plays an important role in tumorigenesis. Cyclin D1 gene (CCND1) is a key regulator of the G1 phase of the cell cycle. Methods: In this case control study of 115 oral premalignant lesion (OPL) patients and 230 controls, we genotyped the CCND1 single nucleotide polymorphism (SNP) at the exon 4 splice site (G870A) and determined the association of this SNP with the risk of developing OPLs. Results: We found significant associations between the heterozygous variant allele (GA), the homozygous variant allele (AA), and OPL risk, with adjusted odds ratios (ORs) of 1.91 (95% CI, 1.05-3.48) and 2.38 (95%CI, 1.16-4.87), respectively. The OR for individuals with at least one variant allele was 2.04 (95%CI, 1.15-3.60). When further stratified analyses were performed, the increased risk was more evident in younger individuals (OR=2.82, 95% CI, 1.32-6.02), in men (OR=2.97, 95%CI, 1.31-6.71), and in never smokers (OR=2.92, 95% CI, 1.09-7.82). Finally, we found joint effects between the variant alleles and smoking status. Using never smokers with the wild type (GG) genotypes as the reference group, the ORs for never smokers with the variant genotypes (G/A + A/A), smokers with the G/G genotype, and smokers with the G/A + A/A genotypes were 2.92 (1.09-7.82), 3.95 (1.36-11.5), and 7.01 (2.68-18.4), respectively. Conclusion: Our results suggest that the CCND1 G870A SNP may contribute to genetic susceptibility to OPLs and involve in oral cancer development.
Received January 1, 2006
Revised April 6, 2006
Accepted April 11, 2006
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION
Cyclin D1 gene polymorphism as a risk factor for oral premalignant lesions
Maosheng Huang 1,
Margaret R. Spitz 1,
Jian Gu 1,
J. Jack Lee 2,
Jie Lin 1,
Scott M. Lippman 3,
and
Xifeng Wu 1 *
2 Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030
3 Department of Thoracic/Head and Neck Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030
Xifeng Wu, E-mail: xwu{at}mdanderson.org
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. L. Goode, B. L. Fridley, R. A. Vierkant, J. M. Cunningham, C. M. Phelan, S. Anderson, D. N. Rider, K. L. White, V. S. Pankratz, H. Song, et al. Candidate Gene Analysis Using Imputed Genotypes: Cell Cycle Single-Nucleotide Polymorphisms and Ovarian Cancer Risk Cancer Epidemiol. Biomarkers Prev., March 1, 2009; 18(3): 935 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Freemantle, Y. Guo, and E. Dmitrovsky Retinoid Chemoprevention Trials: Cyclin D1 in the Crosshairs Cancer Prevention Research, January 1, 2009; 2(1): 3 - 6. [Full Text] [PDF]
|
|
|
|
|
|
V. Papadimitrakopoulou, J. G. Izzo, D. D. Liu, J. Myers, T. L. Ceron, J. Lewin, W. N. William Jr., A. Atwell, J. J. Lee, A. Gillenwater, et al. Cyclin D1 and Cancer Development in Laryngeal Premalignancy Patients Cancer Prevention Research, January 1, 2009; 2(1): 14 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Marsit, C. C. Black, M. R. Posner, and K. T. Kelsey A Genotype-Phenotype Examination of Cyclin D1 on Risk and Outcome of Squamous Cell Carcinoma of the Head and Neck Clin. Cancer Res., April 15, 2008; 14(8): 2371 - 2377. [Abstract] [Full Text] [PDF]
|
|