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Carcinogenesis Advance Access published online on May 12, 2006
Carcinogenesis, doi:10.1093/carcin/bgl056
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Published by Oxford University Press 2006
Received November 4, 2005
Revised April 5, 2006
Accepted April 11, 2006

CARCINOGENESIS

Negative energy balance induced by voluntary wheel running inhibits polyp development in APCMin mice

Lisa H. Colbert 1 *, Volker Mai 2, Janet A. Tooze 3, Susan N. Perkins 4, David Berrigan 4, and Stephen D. Hursting 5

1 Department of Kinesiology and Comprehensive Cancer Center, University of Wisconsin, Madison, WI
2 Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, MD
3 Wake Forest University School of Medicine, Winston-Salem, NC
4 National Cancer Institute, Bethesda, MD
5 Department of Human Ecology, University of Texas, Austin, TX

* To whom correspondence should be addressed.
Lisa H. Colbert, E-mail: lhcolbert{at}education.wisc.edu


  Abstract

Treadmill running of ~0.9 km/day has had inconsistent effects on spontaneous intestinal polyp development in C57BL/6J-ApcMin/J (Min) mice; the amount of energy expenditure and/or a lack of hormonal changes could account for this variability. The purpose of this study was to examine the effects of a negative energy balance induced by voluntary wheel running on polyps, insulin-like growth factor-1 (IGF-1), and corticosterone in Min mice. Seven-week-old male Min mice were randomly assigned to control (CON, n=23) or wheel running (EX, n=24) conditions for a 10-wk study period. All mice had water and AIN-76A diet ad libitum for the first ~3 wks on study, after which the EX group was pair-fed to the CON group to maintain a negative energy balance due to the exercise. EX mice voluntarily ran 3.8 km/d (2.7 - 6.0 km/d) (median, interquartile range) and weighed less than CON mice throughout the study. More CON mice died prior to the end of the study vs. EX mice (26% vs. 0%, p<0.01). CON mice had significantly more polyps vs. EX mice (21.6 ± 1.5 vs. 16.9 ± 2.0, p<0.01; mean ± SE), and daily running distance in EX was inversely correlated with total polyp number (r= -0.70, p<0.01). Urinary corticosterone output (p<0.01), and serum IGF-1 were significantly higher in EX than CON (p<0.001); however, total polyp number was unrelated to corticosterone (r=0.05, p=0.84) and IGF-1 (r=-0.01, p=0.93). In this study, a negative energy balance produced by wheel running exercise and restricted feeding decreased polyp burden in male Min mice and appeared to have a dose-response effect on polyp number. Although EX affected IGF-1 and corticosterone, neither marker was related to total polyp number.


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