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Carcinogenesis Advance Access published online on June 13, 2006
Carcinogenesis, doi:10.1093/carcin/bgl089
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org
Received January 10, 2006
Revised May 9, 2006
Accepted May 9, 2006

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION

Common variants in mismatch repair genes and risk of invasive ovarian cancer

Honglin Song 1 *, Susan J. Ramus 2, Lydia Quaye 2, Richard A. DiCioccio 3, Jonathan Tyrer 1, Emma Lomas 1, Danielle Shadforth 1, Estrid Hogdall 4, Claus Hogdall 4, Valerie McGuire 5, Alice S. Whittemore 5, Douglas F. Easton 6, Bruce A. J. Ponder 1, Susanne Kruger Kjaer 4, Paul D. P. Pharoah 1, and Simon A. Gayther 2

1 CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
2 Translational Research Laboratory, Department of Gynaecological Oncology, University College London, UK
3 Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
4 Department of Viruses, Hormones, and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
5 Department of Health Research and Policy, Stanford University School of Medicine, Stanford, USA
6 CR-UK Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK

* To whom correspondence should be addressed.
Honglin Song, E-mail: honglin{at}srl.cam.ac.uk


  Abstract

Mismatch repair (MMR) is important for repairing of nucleotide mismatches during DNA replication. Germline mutations in MMR genes are associated with heterditary nonpolyposis colorectal cancer (HNPCC). Ovarian cancer occurs as part of the HNPCC phenotype, and so common variants in MMR genes are candidates for ovarian cancer susceptibility. We performed a large multi-centre case-control study to investigate associations of common variations in MMR genes and ovarian cancer using a single nucleotide polymorphism (SNP) tagging approach. A total of 2570 controls and 1531 cases from three separate studies were genotyped for 44 tagging SNPs (stSNP) in seven MMR genes (MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2). Genotype frequencies were marginally different between cases and controls for PMS2 rs7797466 (P2df = 0.046) with a 1.17-fold (95%CI 1.03-1.33) increase in risk for each "a" allele carried (P-trend =0.013). Haplotype analysis of PMS2 also showed significant difference in frequencies between cases and controls (P7df = 0.005), with one haplotype accounting for most of the effect. There was also marginal evidence for a recessive protective effect with common homozygote as the baseline comparator for two SNPs -MSH6 rs3136245 (OR 0.67 95%CI 0.46-0.98) and MSH3 rs6151662 (OR 0.28 95%CI 0.08-0.91) - but the comparisons of genotype frequencies for these variants were not significant (P = 0.10 and 0.054). In conclusion, it is unlikely that common variants in MLH1, MLH3, PMS1, MSH2, MSH3 and MSH6 contribute significantly to ovarian cancer susceptibility. The observed association of PMS2 rs7797466 with ovarian cancer warrants confirmation in an independent study.


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