Carcinogenesis Advance Access published online on July 8, 2006
Carcinogenesis, doi:10.1093/carcin/bgl121
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1 Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, 210029, China
* To whom correspondence should be addressed. Several epidemiological studies have shown that the myeloperoxidase (MPO) G-463A polymorphism may influence the risk of many cancers, including lung, breast, bladder and laryngeal cancer. However, there is no study concerning the MPO polymorphism and gastric cancer risk. In this hospital-based, case-control study, we used polymerase chain reaction-restriction fragment length polymorphism protocols to examine the prevalence of MPO G-463A polymorphism in gastric cancer. A significantly different distribution of the MPO -463G/A genotype was demonstrated among the cases and controls ( Drs. H Zhu and L Yang contributed equally to this work. 1 Project was supported by grants from the National Natural Science Foundation of China (No 30000207), the Natural Science Foundation of Jiangsu Province (No BK2006525), Commercialization of Science and Technology Foundation of Education Department, Jiangsu Province (JH01-050) and Nanjing Medical University grant (CX2001003) to B Wang.
Received May 8, 2006
Revised June 29, 2006
Accepted July 5, 2006
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION
Myeloperoxidase G-463A polymorphism and the risk of gastric cancer: a case-control study1
Huaijun Zhu 1,
Li Yang 2,
Bo Zhou 1,
Rongbin Yu 3,
Naping Tang 1,
and
Bin Wang 1 *
2 Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, 210029, China; Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
3 Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 210029, China
Bin Wang, E-mail: binwang{at}njmu.edu.cn
Abstract 
2=7.42, P=0.03). Subjects with the variant genotypes (the sum of GA and AA) had a 44% reduced risk of gastric cancer relative to those with GG (adjusted OR=0.56; 95% CI: 0.32-0.97). Stratified analyses revealed that the protective effect of A allele was significant in male (adjusted OR=0.51; 95% CI: 0.26-0.98) or younger (age <58 years) (adjusted OR=0.42; 95% CI: 0.18-0.94) subjects, but not in female or older subjects. In addition, there was also a significantly reduced risk in subjects residing in rural areas (adjusted OR=0.41; 95% CI: 0.18-0.95) but not in urban areas. The interaction between the MPO G-463A polymorphism and smoking status was not observed in this study. Tumor differentiation was also not found to be associated with the MPO genotype. In conclusion, our results showed that the MPO -463 G to A variant may be associated with the decreased risk of gastric cancer in Chinese population.
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