Skip Navigation



Carcinogenesis Advance Access published online on September 6, 2006
Carcinogenesis, doi:10.1093/carcin/bgl170
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
28/2/427    most recent
bgl170v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Vogel, U.
Right arrow Articles by Tjønneland, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vogel, U.
Right arrow Articles by Tjønneland, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org
Received April 18, 2006
Revised August 29, 2006
Accepted September 2, 2006

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION

Peroxisome profilerator-activated receptor{gamma}2 Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes

Ulla Vogel 1 *, Jane Christensen 2, Bjørn A. Nexø 3, Håkan Wallin 4, Søren Friis 2, and Anne Tjønneland 2

1 National Institute of Occupational Health, Copenhagen, Denmark; Institute of Life Sciences and Chemistry, Roskilde University, Roskilde
2 Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
3 Institute of Human Genetics, University of Aarhus, Aarhus, Denmark
4 National Institute of Occupational Health, Copenhagen, Denmark

* To whom correspondence should be addressed.
Ulla Vogel, E-mail: ubv{at}ami.dk


  Abstract

Use of NSAIDs has been associated with decreased risk of breast cancer in epidemiological studies. Thus, a high inflammatory response may be associated with increased breast cancer risk. It is thus possible that genetic variations leading to a modified inflammatory response will influence breast cancer risk. The purpose of this study was to determine if polymorphisms associated with an altered inflammatory response are associated with breast cancer risk, and to investigate the possible interaction with lifestyle factors such as alcohol use, smoking and NSAID use. We matched 361 female breast cancer cases with 361 controls, nested within the prospective "Diet, Cancer and Health" study. Carriers of the variant Ala-allele of PPAR{gamma}2Pro12Ala were at lower risk of breast cancer (IRR=0.67, 95%CI=0.46-0.97). This was primarily due to an interaction with alcohol consumption. Alcohol consumption was associated with a 1.21-fold increased risk of breast cancer pr 10 g alcohol/day (95% CI= 1.06-1.35) among homozygous wild type carriers, whereas alcohol was not associated with breast cancer risk among variant allele carriers (P for interaction=0.005). NSAID users, who were carriers of the variant allele of PPAR{gamma}2Pro12Ala, were at lower risk of breast cancer (IRR = 0.44; 95%CI=0.26-0.73) compared with non-users carrying wildtype alleles (P for interaction=0.03). No effects were found for IL6 G-174C, IL8 T-251A and COX2 T8473C. Our results suggest that PPAR{gamma}2Pro12Ala is an important determinant in alcohol mediated breast carcinogenesis. We also observe interaction between NSAID, alcohol consumption and PPAR{gamma}2Pro12Ala genotype in relation to breast cancer risk.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
F. Ondrey
Peroxisome Proliferator-Activated Receptor {gamma} Pathway Targeting in Carcinogenesis: Implications for Chemoprevention
Clin. Cancer Res., January 1, 2009; 15(1): 2 - 8.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
N. G. Venkata, C. S. Aung, P. J. Cabot, G. R. Monteith, and S. J. Roberts-Thomson
PPAR{alpha} and PPAR{beta} Are Differentially Affected by Ethanol and the Ethanol Metabolite Acetaldehyde in the MCF-7 Breast Cancer Cell Line
Toxicol. Sci., March 1, 2008; 102(1): 120 - 128.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.