Skip Navigation



Carcinogenesis Advance Access published online on October 27, 2006
Carcinogenesis, doi:10.1093/carcin/bgl198
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
28/4/828    most recent
bgl198v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Bernig, T.
Right arrow Articles by Ambs, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bernig, T.
Right arrow Articles by Ambs, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press 2006
Received May 20, 2006
Revised October 10, 2006
Accepted October 11, 2006

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION

The mannose-binding lectin (MBL2) haplotype and breast cancer: an association study in African American and Caucasian women

Toralf Bernig 1, Brenda J. Boersma 2, Tiffany M. Howe 2, Robert Welch 3, Sunita Yadavalli 3, Brian Staats 3, Leah E. Mechanic 2, Stephen J. Chanock 1, and Stefan Ambs 2 *

1 Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland
2 Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, Maryland
3 Core Genotyping Facility, NCI, NIH, Bethesda, Maryland

* To whom correspondence should be addressed.
Stefan Ambs, E-mail: ambss{at}mail.nih.gov


  Abstract

Common genetic variants in cancer-related genes contribute to breast cancer. Since the innate immune system plays a crucial role in the immune surveillance against malignancies, it is plausible that genetic variations in key genes of the innate immunity such as the mannose binding lectin, MBL2, could influence the risk for breast cancer. We investigated the association of MBL2 genotypes with breast cancer and conducted a comprehensive genotype and haplotype analysis of 26 MBL2 single nucleotide polymorphisms (SNPs) in a case control study of breast cancer (166 African American case patients versus 180 controls and 127 Caucasian case patients versus 137 controls). We observed that the A allele of the 3' UTR SNP Ex4-1067 (NCBI SNP ID: rs10824792) was significantly associated with a decreased disease risk in African American women [Odds ratio (OR) 0.47, 95% confidence interval (CI) 0.27 - 0.81]. Haplotype analysis of MBL2 showed that the frequency of the corresponding 3' haplotype TATAAC (Ex4-1483, Ex4-1067, Ex4-1047, Ex4-901, Ex4-710, 3238bp 3' STP) was lower in cases than controls among AA women (0.15 versus 0.21; p = 0.02) suggesting a protective effect after adjusting for covariates (OR 0.51, 95% CI 0.29-0.88, p = 0.018). In conclusion, this study presents preliminary evidence that common genetic variants in the 3' UTR of MBL2 might influence the risk for breast cancer in African American women, probably in interaction with the 5' secretor haplotypes that are associated with high concentrations of mannose binding lectin.

Keywords: Breast cancer; mannose-binding lectin; inflammation; innate immunity.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CarcinogenesisHome page
J.-Y. Lee, A. K. Park, K.-M. Lee, S. K. Park, S. Han, W. Han, D.-Y. Noh, K.-Y. Yoo, H. Kim, S. J. Chanock, et al.
Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women
Carcinogenesis, September 1, 2009; 30(9): 1528 - 1531.
[Abstract] [Full Text] [PDF]

Home page
 J Oncol Pharm PractHome page
T. Hogan, Jing Jie Yu, H J. Williams, R. Altaha, Xiaobing Liang, and Qi He
Oncocytic, focally anaplastic, thyroid cancer responding to erlotinib
Journal of Oncology Pharmacy Practice, June 1, 2009; 15(2): 111 - 117.
[Abstract] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
S. R. Pine, L. E. Mechanic, S. Ambs, E. D. Bowman, S. J. Chanock, C. Loffredo, P. G. Shields, and C. C. Harris
Lung Cancer Survival and Functional Polymorphisms in MBL2, an Innate-Immunity Gene
J Natl Cancer Inst, September 19, 2007; 99(18): 1401 - 1409.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. D. Collard, S. K. Shernan, A. A. Fox, T. Bernig, S. J. Chanock, W. K. Vaughn, K. Takahashi, A. B. Ezekowitz, P. Jarolim, and S. C. Body
The MBL2 'LYQA Secretor' Haplotype Is an Independent Predictor of Postoperative Myocardial Infarction in Whites Undergoing Coronary Artery Bypass Graft Surgery
Circulation, September 11, 2007; 116(11_suppl): I-106 - I-112.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.