Carcinogenesis Advance Access published online on October 19, 2006
Carcinogenesis, doi:10.1093/carcin/bgl201
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA; Department of Epidemiology and Biostatistics, Zhejiang University School of Medicine, Hangzhou 310006, China
* To whom correspondence should be addressed. Xeroderma pigmentosum complementation group C (XPC) is responsible for DNA damage recognition in the initial steps of the nucleotide excision repair pathway. Genetic variations in the XPC gene may be associated with impaired protein function and increased risk for bladder cancer. To elucidate the roles of common polymorphisms of XPC in the etiology of bladder cancer, we conducted a hospital-based case-control study including 578 Caucasian incident bladder cancer patients and 578 age- and gender-matched Caucasian controls. We analyzed the associations of the genotypes, haplotypes, and diplotypes of three XPC polymorphisms, Ala499Val (C
Received March 20, 2006
Revised October 9, 2006
Accepted October 11, 2006
MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION
Genotypes, haplotypes, and diplotypes of XPC and risk of bladder cancer
Yimin Zhu 1, Maode Lai 2, Hushan Yang 3, Jie Lin 3, Maosheng Huang 3, H. Barton Grossman 4, Colin P. Dinney 4, and Xifeng Wu 3 *
2 Department of Epidemiology and Biostatistics, Zhejiang University School of Medicine, Hangzhou 310006, China
3 Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
4 Department of Urology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Xifeng Wu, E-mail: xwu{at}mdanderson.org
Abstract 
T), PAT (-/+), and Lys939Gln (AC), with the risk of bladder cancer. No significant association was found for any individual polymorphism. However, the C-C and T-A (indicated as in the order of Ala499Val-PAT-Lys939Gln) haplotypes were associated with reduced bladder cancer risks, with odds ratios (ORs) of 0.51 [95% confidence interval (CI): 0.34-0.78] and 0.79 (0.60-1.04), respectively. The protective effects were more evident in men, people younger than 59 years, and ever-smokers. We also found that four diplotypes were significantly associated with reduced bladder cancer risk, with ORs (and 95% CIs) of 0.53 (0.34-0.82) for C-A/T-A, 0.48 (0.27-0.84) for C-A/C-C, 0.18 (0.053-0.60) for C-C/C-C, and 0.57 (0.36-0.90) for C+C/C+C. These results suggest that sequence variants in the XPC gene might modulate the risk of bladder cancer.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Lu, S. Zhang, D. Chen, H. Wang, W. Wu, X. Wang, Y. Lei, J. Wang, J. Qian, W. Fan, et al. Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility FASEB J, October 1, 2009; 23(10): 3459 - 3469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lin, G. E. Swan, P. G. Shields, N. L. Benowitz, J. Gu, C. I. Amos, M. de Andrade, M. R. Spitz, and X. Wu Mutagen Sensitivity and Genetic Variants in Nucleotide Excision Repair Pathway: Genotype-Phenotype Correlation Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 2065 - 2071. [Abstract] [Full Text] [PDF]
|
|