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Carcinogenesis Advance Access published online on October 27, 2006
Carcinogenesis, doi:10.1093/carcin/bgl205
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org
Received June 12, 2006
Revised October 13, 2006
Accepted October 16, 2006

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION

Apigenin inhibits tumor angiogenesis through decreasing HIF-1{alpha} and VEGF expression

Jing Fang 1 *, Qiong Zhou 1, Ling-Zhi Liu 1, Chang Xia 2, Xiaowen Hu 1, Xianglin Shi 1, and Bing-Hua Jiang 3

1 The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
2 Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506, USA
3 The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506, USA

* To whom correspondence should be addressed.
Jing Fang, E-mail: jfang{at}sibs.ac.cn


  Abstract

Apigenin is a nontoxic dietary flavonoid with anti-tumor properties. We recently showed that apigenin inhibited hypoxia-inducible factor 1 (HIF-1) and VEGF expression in human ovarian cancer cells under normoxic condition. However, the effect of apigenin in angiogenesis remains to be elucidated. Angiogenesis is the formation of new blood vessels and is required for tumor growth and metastasis. In this study, we showed that apigenin inhibited expression of HIF-1 and VEGF in different cancer cells under both normoxic and hypoxic conditions. We demonstrated that apigenin significantly inhibited tumor angiogenesis in vivo, by using both the chicken chorioallantoic membrane and Matrigel plug assays. The inhibition of tumor angiogenesis was associated with the decrease of HIF-1 and VEGF in tumor tissues. Taken together, our results show that apigenin suppresses tumor angiogenesis through HIF-1 and VEGF expression.

Keywords: Apigenin; Angiogenesis; HIF-1; VEGF; Cancer.
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