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Carcinogenesis Advance Access published online on April 9, 2007
Carcinogenesis, doi:10.1093/carcin/bgm083
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© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

MAP17 overexpression is a common characteristic of carcinomas

Maria V. Guijarro1, Juan FM Leal1, Jesus Fominaya1, Carmen Blanco-Aparicio1, Soledad Alonso2, Matilde Lleonart3, Josep Castellvi3, Lidia Ruiz1, Santiago Ramon y Cajal3 and Amancio Carnero1,4

1 Experimental Therapeutics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
2 Molecular Pathology Program, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
3 Dpto. Anatomía Patológica, Hospital Vall d'Hebrón, Barcelona, Spain

4 Address: Experimental Therapeutics Program, Centro Nacional de Investigaciones Oncológicas- (CNIO), Melchor Fernandez Almagro, 3, 28029, Madrid, Spain, Phone: +34 91 732 8021, Fax: +34 91 732 8051, e-mail: acarnero{at}cnio.es

We undertook a large scale genetic screen to identify genes able to alter the cellular response to physiological signals and provide selective advantage once tumorigenesis has begun. We identified MAP17, a small 17 kDa non-glycosylated membrane protein previously identified being overexpressed in carcinomas. We found that MAP17 is overexpressed in a great variety of human carcinomas. Immunohistochemical analysis of MAP17 during cancer progression shows, at least in prostate and ovarian carcinomas, that overexpression of the protein strongly correlates with tumoral progression (P<0.0001). Many tumor cells also express MAP17 and its expression does not correlate with expression of SCL a neighbor gene reported to be co-expressed in some hematopoietic cell lines. SCL neither is expressed in most MAP17 positive tumors, indicating the independent transcription of MAP17, al least in carcinomas. We cloned 5' genomic region to MAP17 and described the minimal promoter necessary to produce independent activation of MAP17. Moreover we have found that MAP17 promoter is activated by oncogenes. Taken together, our data show an independent activation of MAP17 promoter, that can be driven by oncogenes and that might explain the common overexpression of MAP17 in human carcinomas

Key Words: Oncogene • molecular marker • tumor progression • MAP17 • promoter activation

Received February 19, 2007; revised March 29, 2007; accepted March 29, 2007.


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