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Carcinogenesis Advance Access first published online on April 13, 2007
This version published online on April 17, 2007
Carcinogenesis, doi:10.1093/carcin/bgm086
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© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Cancer Genomics: Integrating Form and Function

So Young Kim and William C. Hahn*

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115 and Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142

* Corresponding author: Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115 USA Phone: 617-632-2641 Fax: 617-632-4005, Email: William_Hahn{at}dfci.harvard.edu

The sequencing of the human genome has formed the foundation with which to develop technologies and reagents to perform true genome-scale biological studies. In particular, the development and increasing application of these high-throughput genome scale technologies has fundamentally altered the way one can approach the analysis of cancer. In particular, it is now possible to imagine studies that interrogate the structure, expression and function of every gene in a comprehensive, highly parallel fashion, permitting the development of multidimensional, global views of cancer. In this review we focus on recent advances in the application of genomic strategies to the study of cancer, with an emphasis on functional genomics and the prospects for integrating the knowledge gained from these approaches to further develop our understanding of cancer and design better therapeutic strategies.

The figures have been added in this version.

Received February 27, 2007; revised February 27, 2007; accepted April 2, 2007.


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