Skip Navigation



Carcinogenesis Advance Access published online on May 10, 2007
Carcinogenesis, doi:10.1093/carcin/bgm109
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
28/8/1726    most recent
bgm109v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Bau, D.-T.
Right arrow Articles by Shen, C.-Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bau, D.-T.
Right arrow Articles by Shen, C.-Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

DNA Double-Strand-Break Repair Capacity and Risk of Breast Cancer

Da-Tian Bau1,2, Yi-Chien Mau1, Shian-ling Ding1,3, Pei-Ei Wu1 and Chen-Yang Shen1,4,5

1 Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
2 Cancer Center, China Medical University Hospital, Taichung 40402, Taiwan
3 Department of Nursing, Kang-Ning Junior College of Medical Care and Management, Taipei, 11485, Taiwan
4 Life Science Library, Academia Sinica, Taipei 11529, Taiwan
5 Graduate Institute of Environmental Science, China Medical University, Taichong, 40402, Taiwan

Corresponding author: Dr. Chen-Yang Shen, Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan. Phone: +886-2-27899036, Fax: +886-2-2782 3047. E-mail: bmcys{at}ibms.sinica.edu.tw.

A tumorigenic role of the nonhomologous end-joining (NHEJ) pathway for the repair of DNA double-strand-breaks (DSBs) has been suggested by our finding of a significant association between increased breast cancer risk and a cooperative effect of single nucleotide polymorphisms (SNPs) in NHEJ genes. To confirm this finding, this case-control study detected both in vivo and in vitro DNA end-joining (EJ) capacities in EBV-immortalized peripheral blood mononuclear cells (PBMCs) of 112 breast cancer patients and 108 healthy controls to identify individual differences in EJ capacity to repair DSB as a risk factor predisposing women to breast cancer. PBMCs from breast cancer patients consistently showed lower values of in vivo and in vitro EJ capacities than those from healthy women (P<0.05). Logistic regression, simultaneously considering the effect of known risk factors of breast cancer, shows that the in vitro EJ capacity above the median of control subjects was associated with nearly three-fold increased risks for breast cancer (adjusted odds ratio, 2.98, 95% confidence interval, 1.64-5.43). Furthermore, a dose-response relationship was evident between risk for breast cancer and EJ capacity, which was analyzed as a continuous variable (every unit decrease of EJ capacity being associated with an 1.09-fold increase of breast cancer risk) and was divided into tertiles based on the EJ capacity values of the controls (P for trend < 0.01). The findings support the conclusion that NHEJ may play a role in susceptibility to breast cancer.

Key Words: Double-strand-break • Nonhomologous end-joining • Breast cancer

Received December 29, 2006; revised April 24, 2007; accepted April 30, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anticancer ResHome page
H.-C. WANG, C.-F. CHIU, R.-Y. TSAI, Y.-S. KUO, H.-S. CHEN, R.-F. WANG, C.-W. TSAI, C.-H. CHANG, C.-C. LIN, and D.-T. BAU
Association of Genetic Polymorphisms of EXO1 Gene with Risk of Breast Cancer in Taiwan
Anticancer Res, October 1, 2009; 29(10): 3897 - 3901.
[Abstract] [Full Text] [PDF]

Home page
 Anticancer ResHome page
C.-H. CHANG, R.-F. WANG, R.-Y. TSAI, H.-C. WU, C.-H. WANG, C.-W. TSAI, C.-L. CHANG, Y.-A. TSOU, C.-S. LIU, and D.-T. BAU
Significant Association of XPD Codon 312 Single Nucleotide Polymorphism with Bladder Cancer Susceptibility in Taiwan
Anticancer Res, October 1, 2009; 29(10): 3903 - 3907.
[Abstract] [Full Text] [PDF]

Home page
 Anticancer ResHome page
M.-D. YANG, Y.-M. HSU, Y.-S. KUO, H.-S. CHEN, C.-L. CHANG, C.-N. WU, C.-H. CHANG, Y.-M. LIAO, H.-C. WANG, M.-F. WANG, et al.
Significant Association of Ku80 Single Nucleotide Polymorphisms with Colorectal Cancer Susceptibility in Central Taiwan
Anticancer Res, June 1, 2009; 29(6): 2239 - 2242.
[Abstract] [Full Text] [PDF]

Home page
 Anticancer ResHome page
C.-H. CHANG, C.-L. CHANG, C.-W. TSAI, H.-C. WU, C.-F. CHIU, R.-F. WANG, C.-S. LIU, C.-C. LIN, and D.-T. BAU
Significant Association of an XRCC4 Single Nucleotide Polymorphism with Bladder Cancer Susceptibility in Taiwan
Anticancer Res, May 1, 2009; 29(5): 1777 - 1782.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
N. Machella, M. B. Terry, J. Zipprich, I. Gurvich, Y. Liao, R. T. Senie, D. O. Kennedy, and R. M. Santella
Double-strand breaks repair in lymphoblastoid cell lines from sisters discordant for breast cancer from the New York site of the BCFR
Carcinogenesis, July 1, 2008; 29(7): 1367 - 1372.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.