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Carcinogenesis Advance Access published online on October 4, 2007
Carcinogenesis, doi:10.1093/carcin/bgm200
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© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

NDRG1, a Growth and Cancer Related Gene: Regulation of Gene Expression and Function in Normal and Disease States

Thomas Ellen, Qingdong Ke, Ping Zhang and Max Costa

Dept. of Environmental Medicine, Pharmacology and the NYU Cancer Institute, New York University School of Medicine New York, N.Y. 10016

N-myc downstream-regulated gene 1 (NDRG1) is an intracellular protein that is induced under a wide variety of stress and cell growth-regulatory conditions. NDRG1 is upregulated by cell differentiation signals in various cancer cell lines, and suppresses tumor metastasis. Despite its specific role in the molecular cause of Charcot-Marie-Tooth type 4D disease, there has been more interest in the gene as a marker of tumor progression and enhancer of cellular differentiation. Because it is strongly upregulated under hypoxic conditions, and this condition is prevalent in solid tumors, its regulation is somewhat complex, governed by hypoxia-inducible factor- (HIF-1{alpha}–) and p53-dependent pathways, as well as its namesake, N-Myc, and probably many other factors, at the transcriptional and translational levels, and through mRNA stability. We survey the data for clues to the NDRG1 gene's mechanism, and for indications that the NDRG1 gene may be an efficient diagnostic tool and therapy in many types of cancers.

Received July 9, 2007; revised August 23, 2007; accepted August 26, 2007.


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