Skip Navigation



Carcinogenesis Advance Access published online on October 4, 2007
Carcinogenesis, doi:10.1093/carcin/bgm210
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow Supplementary Data
Right arrow All Versions of this Article:
28/12/2543    most recent
bgm210v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Brenner, A.V.
Right arrow Articles by Inskip, P.D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brenner, A.V.
Right arrow Articles by Inskip, P.D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press 2007.

Single nucleotide polymorphisms in selected cytokine genes and risk of adult glioma

A.V. Brenner, Ph.D.1,*, M.A. Butler, Ph.D.2, S.S. Wang, Ph.D.1, A.M. Ruder, Ph.D.3, N. Rothman, M.D.1, P.A. Schulte, Ph.D.4, S.J. Chanock, M.D.5, H.A. Fine, M.D.6, M.S. Linet, M.D.1 and P.D. Inskip, Sc.D.1

1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS
2 Division of Applied Research and Technology, National Institute for Occupational Safety and Health, CDC, DHHS
3 Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, DHHS
4 Education and Information Division, National Institute for Occupational Safety and Health, CDC, DHHS
5 Core Genotyping facility, Advanced Technology Corp., National Cancer Institute, NIH, DHHS
6 Neurooncology Branch, Center for Cancer Research, National Cancer Institute, NIH, DHHS

* Corresponding author: Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive blvd., EPS 7090, Bethesda, MD 20892-7238, Tel: (301) 402-8680, Fax: (301) 402-0207, e-mail: brennera{at}mail.nih.gov

A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped eleven SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1,190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend=0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend=0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma.

Received June 14, 2007; revised August 24, 2007; accepted September 12, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
P. Rajaraman, A. V. Brenner, M. A. Butler, S. S. Wang, R. M. Pfeiffer, A. M. Ruder, M. S. Linet, M. Yeager, Z. Wang, N. Orr, et al.
Common Variation in Genes Related to Innate Immunity and Risk of Adult Glioma
Cancer Epidemiol. Biomarkers Prev., May 1, 2009; 18(5): 1651 - 1658.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
L. M. Dong, J. D. Potter, E. White, C. M. Ulrich, L. R. Cardon, and U. Peters
Genetic Susceptibility to Cancer: The Role of Polymorphisms in Candidate Genes
JAMA, May 28, 2008; 299(20): 2423 - 2436.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.