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Carcinogenesis Advance Access published online on January 3, 2008
Carcinogenesis, doi:10.1093/carcin/bgm276
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Take a break – resveratrol in action on DNA

Susanne A. Gatz1 and Lisa Wiesmüller2,*

1 University Children's Hospital, Eythstr. 24, D-89075 Ulm, Germany
2 Department of Obstetrics and Gynecology of the University of Ulm, Prittwitzstr. 43, D-89075 Ulm, Germany

* Corresponding author: Lisa Wiesmüller, Department of Obstetrics and Gynecology of the University of Ulm, Prittwitzstr. 43, D-89075 Ulm, Germany; phone: 0049/731/50058800, FAX: 0049/731/50058810, E-mail: lisa.wiesmueller{at}uni-ulm.de

The phytochemical resveratrol (RV) has become a focus of intense research owing to its roles in promoting longevity and in cancer prevention. As an anti-cancer agent RV has primarily been linked to growth and death regulatory pathways. There is now growing evidence that, under physiological conditions, RV additionally contributes to the maintenance of genome stability. Thus, at the stage of DNA damage formation, RV protects the genome as an anti-oxidant via inhibition of inflammation, suppression of metabolic carcinogen activation, de novo expression of genes that encode detoxifying proteins and possibly even via radical scavenging properties. However, results demonstrating RV-dependent DNA breakage in the presence of Cu(II) ions and inhibition of DNA polymerases {alpha} and {delta} produced some controversy regarding RV's role as a caretaker compound. Significantly, recent studies have revealed that activation of ATM and ATR could be a central effect of RV which underlies cell cycle regulation and the newly described activation of fidelity control mechanisms in DNA double-strand break repair (DSB) involving Nbs1 and p53. In this review, we discuss the existing data on RV's direct and indirect effects on genome integrity, in the light of future chemopreventive and chemotherapeutic protocols involving RV or related compounds.

Key Words: Resveratrol • genistein • quercetin • ATM/ATR • SIRT1

Received September 6, 2007; revised November 26, 2007; accepted November 27, 2007.


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