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Carcinogenesis Advance Access published online on June 9, 2008
Carcinogenesis, doi:10.1093/carcin/bgm300
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CYP1B1 variants are associated with Prostate Cancer in non-Hispanic and Hispanic Caucasians

Joke Beuten1, Jonathan A.L. Gelfond2, John J. Byrne1, Ivana Balic3, AnaLisa C. Crandall1, Teresa L. Johnson-Pais4, Ian M. Thompson5, Douglas K. Price6 and Robin J. Leach1,4,5,*

1 Department of Cellular and Structural Biology
2 Department of Epidemiology and Biostatistics
3 Department of Psychiatry
4 Department of Pediatrics
5 Department of Urology, The University of Texas Health Science Center, San Antonio, TX
6 Medical Oncology Branch, National Cancer Institute, Bethesda, MD

* To whom correspondence should be addressed at: Department of Cellular and Structural Biology, University of Texas Health Science Center, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900, Phone: (210) 567-6947, Fax: (210) 567-6781. E-mail: leach{at}uthscsa.edu

Cytochrome P4501B1 (CYP1B1) is involved in the activation of many carcinogens and in the metabolism of steroid hormones. We compared allele, genotype, and haplotype frequencies of 6 single nucleotide polymorphisms (SNPs) within CYP1B1 among non-Hispanic Caucasians (496 cases, 498 controls) and Hispanic Caucasians (153 cases, 240 controls). In the Hispanic Caucasians the GG genotype for rs1056836 decreased the risk for prostate cancer (PCa) when compared to the CC genotype (OR = 0.31, p = 0.04, 95%CI = 0.10-0.96). Among non-Hispanic Caucasian men with more aggressive PCa, the prevalence of several SNPs (rs2567206, rs2551188, rs2617266, rs10012, and rs1056836) was significantly associated with the disease status. A common C-G-C-C-G-A haplotype for rs2567206-rs2551188-rs2617266-rs10012-rs1056836-rs1800440 showed an inverse association with PCa risk in Hispanic Caucasians (OR = 0.19, p = 0.04, 95%CI = 0.04-0.95) and with aggressive disease status (i.e., Gleason score greater than or equal to 7) in non-Hispanic Caucasian cases (OR = 0.64, p = 0.008, 95%CI = 0.47-0.89). In the non-Hispanic Caucasian cases a second major haplotype T-A-T-G-C-A was positively associated with high grade disease status (OR = 1.77, p = 0.002, 94%CI = 1.24-2.53).

Our findings suggest that genetic polymorphisms in CYP1B1 may modify the risk for PCa and support the role of CYP1B1 as a candidate gene for PCa.

Key Words: CYP1B1 • single nucleotide polymorphism • prostate cancer risk

Received August 21, 2007; revised December 20, 2007; accepted December 22, 2007.


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J. Beuten, J. A.L. Gelfond, J. L. Franke, K. S. Weldon, A. C. Crandall, T. L. Johnson-Pais, I. M. Thompson, and R. J. Leach
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[Abstract] [Full Text] [PDF]


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