Skip Navigation



Carcinogenesis Advance Access published online on February 6, 2008
Carcinogenesis, doi:10.1093/carcin/bgn040
This Article
Right arrow Advance Access manuscript (PDF)
Right arrow Supplementary Data
Right arrow Supplementary Data
Right arrow All Versions of this Article:
29/4/880    most recent
bgn040v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Sinnamon, M. J
Right arrow Articles by Matrisian, L. M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sinnamon, M. J
Right arrow Articles by Matrisian, L. M
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

A protective role for mast cells in intestinal tumorigenesis

Mark J Sinnamon1, Kathy J Carter1, Lauren P Sims2, Bonnie LaFleur3, Barbara Fingleton1 and Lynn M Matrisian1,*

1 Department of Cancer Biology, Vanderbilt University, 736 PRB 23rd and Pierce Ave. Nashville, TN. 37232-6840
2 Vanderbilt Microarray Shared Resource, Vanderbilt University, 9274 MRBIII, 465 21st Avenue South, Nashville, TN 37232
3 Department of Biostatistics, Vanderbilt University, Nashville, TN 37232. Current address: University of Utah, Salt Lake City, UT 84112

* Corresponding Author: Prof. Lynn Matrisian, Department of Cancer Biology, Vanderbilt University, 771 PRB, 23rd and Pierce Ave, Nashville, TN, 37232-6840. USA. E-mail: lynn.matrisian{at}vanderbilt.edu

Mast cells have been observed in numerous types of tumors, however, their role in carcinogenesis remains poorly understood. The majority of epidemiological evidence suggests a negative association between the presence of mast cells and tumor progression in breast, lung and colonic neoplasms. Intestinal adenomas in the multiple intestinal neoplasia (Min, APCMin/+) mouse displayed increased numbers of mast cells and increased abundance of mast cell-associated proteinases as determined by transcriptional profiling with the Hu/Mu ProtIn microarray. To examine the role of mast cells in intestinal tumorigenesis, a mutant mouse line deficient in mast cells, Sash mice (c-kitW-sh/W-sh), were crossed with the Min mouse, a genetic model of intestinal neoplasia. The resulting mast cell deficient Min-Sash mice developed 50% more adenomas than littermate controls, and the tumors were 33% larger in Min-Sash mice. Mast cell deficiency did not affect tumor cell proliferation; however, apoptosis was significantly inhibited in mast cell deficient mice. Mast cells have been shown to act as critical upstream regulators of numerous inflammatory cells. Neutrophil, macrophage and T cell populations were similar between Min and Min-Sash mice, however; eosinophils were significantly less abundant in tumors obtained from Min-Sash animals. These results indicate a protective, anti-tumor role for mast cells in a genetic model of early-stage intestinal tumorigenesis.

Key Words: Min • Mast Cells • Inflammation • Cancer • Eosinophils

Received November 9, 2007; revised January 8, 2008; accepted January 29, 2008.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.