Carcinogenesis Advance Access published online on July 14, 2008
Carcinogenesis, doi:10.1093/carcin/bgn166
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Association of Vitamin D Receptor Gene Variants, Adiposity and Colon Cancer
1 Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, New York
2 Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio
3 Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota
4 Department of Family Medicine, Case Western Reserve University/University Hospitals Case Medical Center, Cleveland, Ohio
5 Case Center for Transdisciplinary Research on Energetics and Cancer, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio
6 Cancer Control Program, University of Kentucky, Lexington, Kentucky
7 Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio
8 Department of Preventive Medicine, University of Southern California, Los Angeles, California
Correspondence: Li Li, MD, PhD, Department of Family Medicine-Research Division, Case Western Reserve University, 11001 Cedar Ave., Suite 306, Cleveland, Ohio 44106-7136. E-mail: lxl62{at}cwru.edu
Vitamin D receptor (VDR) gene variants have been variably associated with risk of colon cancer in epidemiologic studies. We sought to further clarify the relationship between colon cancer and 3 single nucleotide polymorphisms (SNPs) in the VDR gene (Cdx-2, FokI, and TaqI) in a population-based case-control study of 250 incident cases and 246 controls. Colon cancer cases were more frequently homozygous for the Cdx-2 A allele (9.2% vs. 4.1%, p = 0.06). Cdx-2 AA homozygotes were at increased risk with an unadjusted odds ratio (OR) of 2.47 [95% confidence interval (CI) = 1.13-5.37, p = 0.022]; adjustment for age, sex, body mass index (BMI), non-steroidal anti-inflammatory use, and family history of colorectal cancer yielded an OR of 2.27 (CI = 0.95-5.41, p = 0.065). Carriers of the FokI TT genotype were also at increased risk with an adjusted OR of 1.87 (CI = 1.03-3.38, p = 0.038). Haplotype analyses showed significant increased colon cancer risk for carriers of the Cdx-2-FokI A-T haplotype and the FokI-TaqI T-G haplotype. The 3-SNP Cdx-2-FokI-TaqI (A-T-G) haplotype showed a similar association with an adjusted OR of 3.63 (CI = 1.01-13.07). A strong positive association was observed for the Cdx-2 variant among individuals with low BMI or low waist circumference. Our results suggest that genetic variation at the VDR locus, in particular Cdx-2 and FokI SNPs, may influence colon cancer risk and these associations may be modified by adiposity.
Received March 27, 2008; revised July 8, 2008; accepted July 9, 2008.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Jenab, J. McKay, H. B. Bueno-de-Mesquita, F. J.B. van Duijnhoven, P. Ferrari, N. Slimani, E. H.J.M. Jansen, T. Pischon, S. Rinaldi, A. Tjonneland, et al. Vitamin D Receptor and Calcium Sensing Receptor Polymorphisms and the Risk of Colorectal Cancer in European Populations Cancer Epidemiol. Biomarkers Prev., September 1, 2009; 18(9): 2485 - 2491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Raimondi, H. Johansson, P. Maisonneuve, and S. Gandini Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk Carcinogenesis, July 1, 2009; 30(7): 1170 - 1180. [Abstract] [Full Text] [PDF]
|
|