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Carcinogenesis Advance Access published online on October 28, 2008
Carcinogenesis, doi:10.1093/carcin/bgn244
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Apigenin Inhibited Migration and Invasion of Human Ovarian Cancer A2780 Cells through Focal Adhesion Kinase

Xiao-Wen Hu1, Dan Meng1 and Jing Fang1,*

1 Key Laboratory of Nutrition and Metabolism, Institute of Nutritional Sciences, Shanghai Institute for Biological Sciences, The Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031

* Correspondence: Jing Fang, Key Laboratory of Nutrition and Metabolism, Institute of Nutritional Sciences, SIBS, Chinese Academy of Sciences. Email: jfang{at}sibs.ac.cn. Tel: 86-21-54920241. Fax: 86-21-54920291.

Apigenin, a common dietary flavonoid, has been found to have anti-tumor properties and therefore poses special interest for the development of chemopreventive and/or chemotherapeutic agent for cancers. Here we demonstrate that apigenin inhibits expression of focal adhesion kinase (FAK) and migration and invasion of human ovarian cancer A2780 cells. FAK is a non-receptor protein tyrosine kinase downstream of integrins and growth factors. It plays an important role in migration and invasion of cancer cells. We found that apigenin inhibited adhesion, migration and invasion of A2780 cells. Apigenin attenuated FAK expression through reducing its protein stability. FAK plays a critical role in migration and invasion of A2780 cells. Overexpression of FAK could reverse A2780 cell migration and invasion inhibited by apigenin. The in vivo experiments showed that apigenin inhibited spontaneous metastasis of A2780 cells implanted onto the ovary of nude mice. Our results provide a new insight into the mechanisms that apigenin inhibits ovarian cancers. These results suggest that molecular targeting of FAK by apigenin might be a useful strategy for chemoprevention and/or chemotherapeutics of ovarian cancers.

Key Words: Apigenin • Focal adhesion kinase • migration • invasion • ovarian cancer

Received July 4, 2008; revised September 26, 2008; accepted October 20, 2008.


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