Skip Navigation



Carcinogenesis Advance Access published online on March 2, 2009
Carcinogenesis, doi:10.1093/carcin/bgp055
This Article
Right arrow Advance Access manuscript (PDF)
Right arrow Supplementary Data
Right arrow All Versions of this Article:
30/5/769    most recent
bgp055v2
bgp055v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ahn, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ahn, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press 2009.

Vitamin D-related Genes, Serum Vitamin D Concentrations, and Prostate Cancer Risk

Jiyoung Ahn1, Demetrius Albanes1, Sonja I. Berndt1, Ulrike Peters2, Nilanjan Chatterjee1, Neal D. Freedman1, Christian C. Abnet1, Wen-Yi Huang1, Adam S. Kibel3, E. David Crawford4, Stephanie J. Weinstein1, Stephen J. Chanock1, Arthur Schatzkin1, Richard B. Hayes1 and for the Prostate, Lung, Colorectal, and Ovarian (PLCO) Trial Project Team

1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD
2 Cancer Prevention Program, Fred Hutchinson Cancer Research Center and Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA
3 Division of Urologic Surgery, Washington University School of Medicine, St. Louis, MO
4 Anschutz Cancer Pavilion University of Colorado, MS 710, Aurora, CO

Correspondence to: Jiyoung Ahn, PhD, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Bethesda, MD 20892; Ahnj{at}mail.nih.gov

We systematically investigated the association of 48 SNPS in four vitamin D metabolizing genes (CYP27A1, GC, CYP27B1, and CYP24A1) with serum 25(OH)D and 1,25(OH)D levels and the association of these SNPS and an additional 164 SNPS in 8 downstream mediators of vitamin D signaling (VDR, RXRA, RXRB, PPAR, NCOA1, NCOA2, NCOA3, and SMAD3) with prostate cancer risk in the 749 incident prostate cancer cases and 781 controls of the PLCO trial. 25(OH)D (all cases and controls) and 1,25(OH)D (a subset of 150 controls) levels were measured by radioimmunoassay and SNP data were genotyped as part of a genome-wide scan. Among investigated SNPS, only four tagSNPS in GC, the major serum 25(OH)D carrier, were associated with 25(OH)D levels; no SNPS were associated with 1,25(OH)D levels. None of the 212 SNPS examined were associated with cancer risk overall. Among men in the lowest tertile of serum 25(OH)D (<48.9 nmol/l), however, prostate cancer risk was related to tagSNPS in or near the 3' untranslated region of VDR, with the strongest association for rs11574143 [OR (95%CI) for risk allele carriers vs wildtype: 2.49(1.51-4.11), p = 0.0007]; the genotype associations were null among men in tertile 2 and tertile 3. Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tagSNPS in the 3’untranslated region of VDR, may be associated with risk of prostate cancer in men with low vitamin D status.

Key Words: Vitamin D • genetic polymorphism • prostate cancer

Received December 31, 2008; revised February 14, 2009; accepted February 18, 2009.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
H. G. Skinner and G. G. Schwartz
The Relation of Serum Parathyroid Hormone and Serum Calcium to Serum Levels of Prostate-Specific Antigen: A Population-Based Study
Cancer Epidemiol. Biomarkers Prev., November 1, 2009; 18(11): 2869 - 2873.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.