Skip Navigation



Carcinogenesis Advance Access published online on April 9, 2009
Carcinogenesis, doi:10.1093/carcin/bgp082
This Article
Right arrow Advance Access manuscript (PDF)
Right arrow Supplementary Data
Right arrow All Versions of this Article:
30/6/1016    most recent
bgp082v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Dance-Barnes, S. T.
Right arrow Articles by Miller, M. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dance-Barnes, S. T.
Right arrow Articles by Miller, M. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Lung tumor promotion by curcumin

Stephanie T. Dance-Barnesa, Nancy D. Kockb, Joseph E. Moorea, Elaine Y. Line, Libyadda J. Mosleya, Ralph B. D'Agostino, Jr.c, Thomas P. McCoyc, Alan J. Townsendd and Mark Steven Millera,*

a Department of Cancer Biology
b Section on Comparative Medicine, Department of Pathology
c Department of Biostatistical Sciences
d Biochemistry and Molecular Biology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157
e Department of Medicine, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, NY 10467

* Corresponding author: Dr. Mark Steven Miller, Department of Cancer Biology, 1 Medical Center Blvd., Wake Forest University School of Medicine, Comprehensive Cancer Center, Winston-Salem, NC 27157 Phone: 336-716-0795, Fax: 336-716-0255, E-Mail: msmiller{at}wfubmc.edu.

Curcumin exhibits anti-inflammatory and anti-tumor activity and is being tested in clinical trials as a chemopreventive agent for colon cancer. Curcumin's chemopreventive activity was tested in a transgenic mouse model of lung cancer that expresses the human Ki-rasG12C allele in a doxycycline (DOX) inducible and lung-specific manner. The effects of curcumin were compared to the lung tumor promoter, butylated hydroxytoluene (BHT), and the lung cancer chemopreventive agent, sulindac. Treatment of DOX-induced mice with dietary curcumin increased tumor multiplicity (36.3±0.9 vs. 24.3±0.2) and progression to later stage lesions, results which were similar to animals that were co-treated with DOX/BHT. Microscopic examination showed that the percentage of lung lesions that were adenomas and adenocarcinomas increased to 66% in DOX/BHT, 66% in DOX/curcumin, and 49% in DOX/BHT/curcumin treated groups relative to DOX only treated mice (19%). Immunohistochemical analysis also showed increased evidence of inflammation in DOX/BHT, DOX/curcumin, and DOX/BHT/curcumin mice relative to DOX only treated mice. In contrast, co-treatment of DOX/BHT mice with 80 ppm of sulindac inhibited the progression of lung lesions and reduced the inflammation. Lung tissue from DOX/curcumin treated mice demonstrated a significant increase (33%; p = 0.01) in oxidative damage, as assessed by the levels of carbonyl protein formation, relative to DOX-treated control mice after one week on the curcumin diet. These results suggest that curcumin may exhibit organ-specific effects to enhance reactive oxygen species formation in the damaged lung epithelium of smokers and ex-smokers. Ongoing clinical trials thus may need to exclude smokers and ex-smokers in chemopreventive trials of curcumin.

Received September 12, 2008; revised March 27, 2009; accepted March 27, 2009.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CarcinogenesisHome page
S.J. Moghaddam, P. Barta, S.G. Mirabolfathinejad, Z. Ammar-Aouchiche, N. T. Garza, T.T. Vo, R. A. Newman, B. B. Aggarwal, C. M. Evans, M. J. Tuvim, et al.
Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice
Carcinogenesis, November 1, 2009; 30(11): 1949 - 1956.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.