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Carcinogenesis Advance Access published online on April 15, 2009
Carcinogenesis, doi:10.1093/carcin/bgp087
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Interaction between HSP60 and β-catenin promotes metastasis

Ya-Ping Tsai1, Muh-Hwa Yang2,3,5, Chi-Hung Huang6, Shyue-Yih Chang4,5, Po-Min Chen3,5, Chung-Ji Liu7, Shu-Chun Teng8 and Kou-Juey Wu1,2,5,*

1 Institutes of Biochemistry & Molecular Biology
2 Clinical Medicine, National Yang-Ming University, Taipei 112
3 Division of Oncology, Departments of Medicine
4 Otolaryngology
5 Genomic Medicine Center, Taipei Veterans General Hospital, Taipei 112
6 Institute of Biochemistry, National Chung-Hsing University, Taichung 402
7 Department of Dentistry, Taipei Mackay Memorial Hospital, Taipei 104
8 Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan

* To whom reprint requests should be addressed. Email: kjwu2{at}ym.edu.tw, Tel: 011886-228267328, Fax: 011886-228264843

Heat shock protein 60 (HSP60) plays an essential role in assisting many newly synthesized proteins to reach their native forms. Increased HSP60 expression is observed in different types of human cancers with metastasis (e.g. pancreatic cancer, large bowel carcinoma). However, the role of HSP60 in metastasis remains little known. Aberrant activation of β-catenin plays a key role in tumorigenesis and metastasis. Here we show that overexpression of HSP60 induces metastatic phenotypes in vitro and in vivo. HSP60 interacts with β-catenin, increases β-catenin protein levels through the apical domain, and enhances its transcriptional activity. Short-interference RNA (siRNA) mediated repression of β-catenin reverts metastatic activity caused by HSP60 overexpression. Proteosomal activity is not required for the induction of β-catenin by HSP60. Co-expression of HSP60 and nuclear β-catenin predicts a worse prognosis of metastatic head and neck cancer patients. These results implicate a novel role of HSP60 in metastasis.

Key Words: HSP60 • β-catenin • metastasis

Received July 1, 2008; revised April 2, 2009; accepted April 7, 2009.


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