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Carcinogenesis Advance Access published online on April 15, 2009
Carcinogenesis, doi:10.1093/carcin/bgp091
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population

Meilin Wang1,2,{dagger}, Miaomiao Wang1,{dagger}, Wei Zhang3, Lin Yuan1, Guangbo Fu4, Qingyi Wei5 and Zhengdong Zhang1,2,*

1 Department of Molecular & Genetic Toxicology, Cancer Center of Nanjing Medical University, Nanjing 210029, China
2 Department of Epidemiology & Biostatistics, Cancer Center of Nanjing Medical University, Nanjing 210029, China
3 Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
4 Department of Urology, The Huai-An First Affiliated Hospital of Nanjing Medical University, Huai-An 223300, China
5 Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA

* Correspondence to: Zhengdong Zhang, Department of Molecular & Genetic Toxicology, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China. Tel: +86 25 86862937; Fax: +86 25 86527613; Email: zdzhang{at}njmu.edu.cn

A recent genome-wide association (GWA) study identified two common variants that confer susceptibility to bladder cancer. We hypothesized that these variants are associated with risk of bladder cancer in Chinese populations. We genotyped rs9642880 G>T on 8q24 and rs710521 A>G on 3q28 in a two-stage case-control study of bladder cancer to evaluate the association and further examined the expression of MYC. We found that the rs9642880 G>T, but not the rs710521 A>G polymorphism, was associated with an increased risk of bladder cancer. Compared with the rs9642880 GG genotype, the GT/TT genotypes were associated with an odd ratio (OR) of 1.65 (95% confidence interval [CI] = 1.25-2.17), and this risk was more pronounced in young men and for low-risk tumors. Additional experiments revealed that the rs9642880 GT/TT genotypes were associated with enhanced levels of both MYC mRNA and protein in bladder tissues. Our findings of the replication suggested that the rs9642880 G>T polymorphism on 8q24 independently was associated with the risk of bladder cancer in Chinese populations.

Key Words: genome-wide association • genetic susceptibility • MYC • bladder cancer • molecular epidemiology

{dagger} These authors contributed equally to this work.

Received February 4, 2009; revised April 8, 2009; accepted April 10, 2009.


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