Carcinogenesis Advance Access published online on June 11, 2009
Carcinogenesis, doi:10.1093/carcin/bgp123
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Novel Single Nucleotide Polymorphism Associations with Colorectal Cancer on Chromosome 8q24 in African and European Americans
Department of Medicine, Sections of Gastroenterology and Genetic Medicine, University of Chicago Medical Center, Chicago, IL
2 Correspondence to: Rick A. Kittles, Department of Medicine, Section of Genetic Medicine, University of Chicago Medical Center, MC 6091, Chicago, IL 60637, (773) 834-2271 office, (773) 702-2567 fax, rkittles{at}medicine.bsd.uchicago.edu
Regions on chromosome 8q24 harbor susceptibility alleles for multiple cancers including colorectal (region 3) and prostate cancer (regions 1-4). The objectives of the present study were: 1) to test whether SNPs in region 4 are associated with colorectal cancer in European or African Americans, 2) to test whether 8q24 SNPs previously shown to be associated with colorectal and prostate cancer also show association in our multi-ethnic series, and 3) to test for association between 100 ancestry informative markers (AIMs) and colorectal cancer in both the African American and European American cohorts. In total, we genotyped nine markers on 8q24 and 100 unlinked AIMs in 569 colorectal cancer cases and 439 controls (490 European Americans and 518 African Americans) obtained retrospectively from a hospital-based sample. We found rs7008482 in 8q24 region 4 to be significantly associated with colorectal cancer in European Americans (p = 0.03). Also in region 4, we found that a second SNP, rs16900305, trended toward association with colorectal cancer in African Americans. rs6983267 in region 3, previously implicated in colorectal cancer risk, trended toward association with disease in European Americans but not in African Americans. Finally, none of the 100 AIMs tested for association reached statistical significance after correction for multiple hypothesis testing. In summary, these results are evidence that 8q24 region 4 contains novel colorectal cancer-associated alleles in European and African Americans.
Key Words: colorectal cancer • African Americans • single nucleotide polymorphisms
1 This work was supported by The Cancer Research Foundation, the Department of Medicine at the University of Chicago, the Digestive Disease Research Core Center (P30 DK42086), NIH National Service Research Award (1F32CA132493 to S.S.K.), Department of Defense (DAMD W81XWH-07-1-0203 to R.A.K.), and the University of Chicago Cancer Center.
Received December 10, 2008; revised May 12, 2009; accepted May 14, 2009.