Carcinogenesis

EDITORIAL:

M. W. Anderson and R. R. Maronpot

Methylene chloride-induced tumorigenesis
Carcinogenesis 1993 14: 787-788; doi:10.1093/carcin/14.5.787 [PDF] [Request Permissions]  

Maria Zielenska, Alia Ahmed, Malgorzata Pienkowska, Marshall Anderson, and Barry W. Glickman

Mutational specificities of environmental carcinogens in the lacI gene of Escherichia coli. VI: analysis of methylene chloride-induced mutational distribution in Uvr⁺ and UvrB^– strains
Carcinogenesis 1993 14: 789-794; doi:10.1093/carcin/14.5.789 [Abstract] [PDF] [Request Permissions]  

Theodora R. Devereux, Julie F. Foley, Robert R. Maronpot, Frank Kari, and Marshall W. Anderson

Ras proto-oncogene activation in liver and lung tumors from B6C3F1 mice exposed chronically to methylene chloride
Carcinogenesis 1993 14: 795-801; doi:10.1093/carcin/14.5.795 [Abstract] [PDF] [Request Permissions]  

Monika E. Hegi, Peter Söderkvist, Julie F. Foley, Robert Schoonhoven, James A. Swenberg, Frank Kari, Robert Maronpot, Marshall W. Anderson, and Roger W. Wiseman

Characterization of p53 mutations in methylene chloride-induced lung tumors from B6C3F1 mice
Carcinogenesis 1993 14: 803-810; doi:10.1093/carcin/14.5.803 [Abstract] [PDF] [Request Permissions]  

Julie F. Foley, Paul D. Tuck, Thai-Vu T. Ton, Monica Frost, Frank Kari, Marshall W. Anderson, and Robert R. Maronpot

Inhalation exposure to a hepatocarcinogenic concentration of methylene chloride does not induce sustained replicative DNA synthesis in hepatocytes of female B6C3F1 mice
Carcinogenesis 1993 14: 811-817; doi:10.1093/carcin/14.5.811 [Abstract] [PDF] [Request Permissions]  

F.W. Kari, J.F. Foley, S.K. Seilkop, R.R. Maronpot, and M.W. Anderson

Effect of varying exposure regimens on methylene chloride-induced lung and liver tumors in female B6C3F1 mice
Carcinogenesis 1993 14: 819-826; doi:10.1093/carcin/14.5.819 [Abstract] [PDF] [Request Permissions]  

ACCELERATED PAPER:

Laurie Delmolino, Hamid Band, and Vimla Band

Expression and stability of p53 protein in normal human mammary epithelial cells
Carcinogenesis 1993 14: 827-832; doi:10.1093/carcin/14.5.827 [Abstract] [PDF] [Request Permissions]  

Teresa A. Lehman, Rama Modali, Petra Boukamp, Julie Stanek, William P. Bennett, Judith A. Welsh, Robert A. Metcalf, Martha R. Stampfer, Norbert Fusenig, Eileen M. Rogan, and Curtis C. Harris

p53 Mutations in human immortalized epithelial cell lines
Carcinogenesis 1993 14: 833-839; doi:10.1093/carcin/14.5.833 [Abstract] [PDF] [Request Permissions]  

ORIGINAL ARTICLES:

Lihong Wei, Huachen Wei, and Krystyna Frenkel

Sensitivity to tumor promotion of SENCAR and C57BL/6J mice correlates with oxidative events and DNA damage
Carcinogenesis 1993 14: 841-847; doi:10.1093/carcin/14.5.841 [Abstract] [PDF] [Request Permissions]  

Santosh K. Katiyar, Rajesh Agarwal, M.Tarif Zaim, and Hasan Mukhtar

Protection against N-nitrosodiethylamine and benzo[a]pyrene-induced forestomach and lung tumorigenesis in A/J mice by green tea
Carcinogenesis 1993 14: 849-855; doi:10.1093/carcin/14.5.849 [Abstract] [PDF] [Request Permissions]  

Jer-Yuh Liu, Su-Ju Lin, and Jen-Kun Lin

Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells
Carcinogenesis 1993 14: 857-861; doi:10.1093/carcin/14.5.857 [Abstract] [PDF] [Request Permissions]  

Takemi Kinouchi, Keiko Kataoka, Koichi Miyanishi, Shigeru Akimoto, and Yoshinari Ohnishi

Biological activities of the intestinal microflora in mice treated with antibiotics or untreated and the effects of the microflora on absorption and metabolic activation of orally administered glutathione conjugates of K-region epoxides of 1-nitropyrene
Carcinogenesis 1993 14: 869-874; doi:10.1093/carcin/14.5.869 [Abstract] [PDF] [Request Permissions]  

Sheila Higginbotham, N.V.S. RamaKrishna, Sonny L. Johansson, Eleanor G. Rogan, and Ercole L. Cavalieri

Tumor-initiating activity and carcinogenicity of dibenzo[a,l]pyrene versus 7, 12-dimethylbenz[a]anthracene and benzo[a]pyrene at low doses in mouse skin
Carcinogenesis 1993 14: 875-878; doi:10.1093/carcin/14.5.875 [Abstract] [PDF] [Request Permissions]  

Bhagavatula Moorthy, Shuo Chen, Donghui Li, and Kurt Randerath

3-Methylcholanthrene-inducible liver cytochrome(s) P450 in female Sprague-Dawley rats: possible link between P450 turnover and formation of DNA adducts and I-compounds
Carcinogenesis 1993 14: 879-886; doi:10.1093/carcin/14.5.879 [Abstract] [PDF] [Request Permissions]  

Halfdan Sørbye, Steinar Kvinnsland, and Knut Svanes

Penetration of N-methyl-N'-nitro-N-nitrosoguanidine to proliferative cells in gastric mucosa of rats is different in pylorus and fundus and depends on exposure time and solvent
Carcinogenesis 1993 14: 887-892; doi:10.1093/carcin/14.5.887 [Abstract] [PDF] [Request Permissions]  

Satram R. Babu, V.Jon Wongsurawat, Terry V. Zenser, and Bernard B. Davis

Benzidine glucuronidation in dog liver
Carcinogenesis 1993 14: 893-897; doi:10.1093/carcin/14.5.893 [Abstract] [PDF] [Request Permissions]  

Shigeo Manabe, Hiramitsu Suzuki, Osamu Wada, and Akira Ueki

Detection of the carcinogen 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) in beer and wine
Carcinogenesis 1993 14: 899-901; doi:10.1093/carcin/14.5.899 [Abstract] [PDF] [Request Permissions]  

Shigeo Manabe, Nobutaka Kurihara, Toshiaki Shibutani, Osamu Wada, Akira Ueki, and Hiramitsu Suzuki

Nucleic acids induce the formation of a carcinogen, 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) in a model system
Carcinogenesis 1993 14: 903-906; doi:10.1093/carcin/14.5.903 [Abstract] [PDF] [Request Permissions]  

A. Sheikh, A. Yusuf, E. Laconi, P.M. Rao, S. Rajalakshmi, and D.S.R. Sarma

Effect of orotic acid on in vivo DNA synthesis in hepatocytes of normal rat liver and in hepatic foci/nodules
Carcinogenesis 1993 14: 907-912; doi:10.1093/carcin/14.5.907 [Abstract] [PDF] [Request Permissions]  

Weiping Zhen, Michele K. Evans, Cynthia M. Haggerty, and Vilhelm A. Bohr

Deficient gene specific repair of cisplatin-induced lesions in Xeroderma pigmentosum and Fanconi's anemia cell lines
Carcinogenesis 1993 14: 919-924; doi:10.1093/carcin/14.5.919 [Abstract] [PDF] [Request Permissions]  

S. van den Berg, H.J. Rahmsdorf, P. Herrlich, and B. Kaina

Overexpression of c-fos increases recombination frequency in human osteosarcoma cells
Carcinogenesis 1993 14: 925-928; doi:10.1093/carcin/14.5.925 [Abstract] [PDF] [Request Permissions]  

Benito Monis and Mirta A. Valentich

Promoting effects of mancozeb on pancreas of nitrosomethylureatreated rats
Carcinogenesis 1993 14: 929-933; doi:10.1093/carcin/14.5.929 [Abstract] [PDF] [Request Permissions]  

Fa-Xian Chen, Yi Zhang, Kevin M. Church, William J. Bodell, and Barry Gold

DNA crosslinking, sister chromatid exchange and cytotoxicity of N-2-chloroethylnitrosoureas tethered to minor groove binding peptides
Carcinogenesis 1993 14: 935-940; doi:10.1093/carcin/14.5.935 [Abstract] [PDF] [Request Permissions]  

María-Jesús Miró-Obradors, Jesús Osada, Hortensia Aylagas, Inmaculada Sánchez-Vegazo, and Evangelina Palacios-Alaiz

Microsomal sphingomyelin accumulation in thioacetamide-injured regenerating rat liver: involvement of sphingomyelin synthase activity
Carcinogenesis 1993 14: 941-946; doi:10.1093/carcin/14.5.941 [Abstract] [PDF] [Request Permissions]  

A.Shobha Rani, Da-Qin Qu, Maninder K. Sidhu, Fotinos Panagakos, Varsha Shah, Kenneth M. Klein, Nicholas Brown, Sen Pathak, and Suriender Kumar

Transformation of immortal, non-tumorigenic osteoblast-like human osteosarcoma cells to the tumorigenic phenotype by nickel sulfate
Carcinogenesis 1993 14: 947-953; doi:10.1093/carcin/14.5.947 [Abstract] [PDF] [Request Permissions]  

Christopher D. Cain, Deborah L. Thomas, and W. Ross Adey

60 Hz magnetic field acts as co-promoter in focus formation of C3H/10T1/2 cells
Carcinogenesis 1993 14: 955-960; doi:10.1093/carcin/14.5.955 [Abstract] [PDF] [Request Permissions]  

F.P. Perera, D.L. Tang, J.P. O'Neill, W.L. Bigbee, R.J. Albertini, R. Santella, R. Ottman, W.Y. Tsai, C. Dickey, L.A. Mooney, K. Savela, and K. Hemminki

HPRT and glycophorin A mutations in foundry workers: relationship to PAH exposure and to PAH-DNA adducts
Carcinogenesis 1993 14: 969-973; doi:10.1093/carcin/14.5.969 [Abstract] [PDF] [Request Permissions]  

Jeannette M. Dypbukt, Luigi Atzori, Charlotte C. Edman, and Roland C. Grafström

Thiol status and cytopathological effects of acrolein in normal and xeroderma pigmentosum skin fibroblasts
Carcinogenesis 1993 14: 975-980; doi:10.1093/carcin/14.5.975 [Abstract] [PDF] [Request Permissions]  

M.J. Donnelly, V. Patel, W.A. Yeudall, S.M. Game, C. Scully, and S.S. Prime

Autocrine production of TGF- and TGF-ß during tumour progression of rat oral keratinocytes
Carcinogenesis 1993 14: 981-985; doi:10.1093/carcin/14.5.981 [Abstract] [PDF] [Request Permissions]  

I.C. Hsu, T. Tokiwa, W. Bennett, R.A. Metcalf, J.A. Welsh, T. Sun, and C.C. Harris

p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines
Carcinogenesis 1993 14: 987-992; doi:10.1093/carcin/14.5.987 [Abstract] [PDF] [Request Permissions]  

Ao Pung, Adrian Franke, Li-Xin Zhang, Hans Ippendorf, Hans-Dieter Martin, Helmut Sies, and John S. Bertram

A synthetic C22 carotenoid inhibits carcinogen-induced neoplastic transformation and enhances gap junctional communication
Carcinogenesis 1993 14: 1001-1005; doi:10.1093/carcin/14.5.1001 [Abstract] [PDF] [Request Permissions]  

Bettina Grasl-Kraupp, Wolfgang Huber, Wilhelm Just, Gordon Gibson, and Rolf Schulte-Hermann

Enhancement of peroxisomal enzymes, cytochrome P-452 and DNA synthesis in putative preneoplastic foci of rat liver treated with the peroxisome proliferator nafenopin
Carcinogenesis 1993 14: 1007-1012; doi:10.1093/carcin/14.5.1007 [Abstract] [PDF] [Request Permissions]  

J.B. Guttenplan

Effects of cytosol on mutagenesis induced by N-nitrosodimethylamine, N-nitrosomethylurea and -acetoxy-N-nitrosodimethylamine in different strains of Salmonella: evidence for different ultimate mutagens from N-nitrosodimethylmine
Carcinogenesis 1993 14: 1013-1019; doi:10.1093/carcin/14.5.1013 [Abstract] [PDF] [Request Permissions]  

Margery K. Herrington, Johan Permert, Katherine R. Kazakoff, Parviz M. Pour, Karl A. Zuker, Anton J. Bilchik, and Thomas E. Adrian

Effects of high fat diet and cholecystokinin receptor blockade on pancreatic growth and tumor initiation in the hamster
Carcinogenesis 1993 14: 1021-1026; doi:10.1093/carcin/14.5.1021 [Abstract] [PDF] [Request Permissions]  

J.G. Shepherd, J.-R. Chen, M.-S. Tsao, and W.P. Duguid

Neoplastic transformation of propagable cultured rat pancreatic duct epithelial cells by azaserine and streptozotocin
Carcinogenesis 1993 14: 1027-1033; doi:10.1093/carcin/14.5.1027 [Abstract] [PDF] [Request Permissions]  

Marie H.Hanigan, Mary L. Winkler, and Norman R. Drinkwater

Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice
Carcinogenesis 1993 14: 1035-1040; doi:10.1093/carcin/14.5.1035 [Abstract] [PDF] [Request Permissions]  

C.E. Scharping, C.C. Duke, G.M. Holder, and D. Larden

The hepatic metabolism of two methylquinolines
Carcinogenesis 1993 14: 1041-1047; doi:10.1093/carcin/14.5.1041 [Abstract] [PDF] [Request Permissions]  

ORIGINAL PAPERS:

Jürgen Fuchs, Jiri Mlcoch, Karl-Ludwig Platt, and Franz Oesch

Characterization of highly polar bis-dihydrodiol epoxide—DNA adducts formed after metabolic activation of dibenz[a,h]anthracene
Carcinogenesis 1993 14: 863-867; doi:10.1093/carcin/14.5.863 [Abstract] [PDF] [Request Permissions]  

Susan P. LeDoux, Nancy J. Patton, Letetia J. Avery, and Glenn L. Wilson

Repair of N-methylpurines in the mitochondrial DNA of xeroderma pigmentosum complementation group D cells
Carcinogenesis 1993 14: 913-917; doi:10.1093/carcin/14.5.913 [Abstract] [PDF] [Request Permissions]  

Stephen P. Povoski, Cecilia M. Fenoglio-Preiser, Hazel J. Sayers, Patrick J. McCullough, Weigong Zhou, and Richard H.Bell, Jr

Effect of streptozotocin diabetes on development of nitrosamine-induced pancreatic carcinoma when diabetes induction occurs after nitrosamine exposure
Carcinogenesis 1993 14: 961-967; doi:10.1093/carcin/14.5.961 [Abstract] [PDF] [Request Permissions]  

Clifford A. Rinehart, Caroline H. Laundon, John P. Mayben, Beverly D. Lyn-Cook, and David G. Kaufman

Conditional immortalization of human endometrial stromal cells with a temperature-sensitive simian virus 40
Carcinogenesis 1993 14: 993-999; doi:10.1093/carcin/14.5.993 [Abstract] [PDF] [Request Permissions]  

SHORT COMMUNICATION:

Junxin Chen, Michael C. MacLeod, Rushen Zhao, and Nicholas E.Geacintov

Fluorescence HPLC methods for detecting benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide-deoxyadenosine adducts in enzyme-digests of modified DNA: improved sensitivity
Carcinogenesis 1993 14: 1049-1051; doi:10.1093/carcin/14.5.1049 [Abstract] [PDF] [Request Permissions]  

Ainsley Weston, Elise D. Bowman, Paula Carr, Nathaniel Rothman, and Paul T.Strickland

Detection of metabolites of polycyclic aromatic hydrocarbons in human urine
Carcinogenesis 1993 14: 1053-1055; doi:10.1093/carcin/14.5.1053 [Abstract] [PDF] [Request Permissions]  

Jian-Min Chen, Yang-Pei Zhang, Robert C.Moschel, and Mituo Ikenaga

Depletion of O⁶-methylguanine—DNA methyltransferase and potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea antitumor activity by O⁶-benzylguanine in vitro
Carcinogenesis 1993 14: 1057-1060; doi:10.1093/carcin/14.5.1057 [Abstract] [PDF] [Request Permissions]  

Hiroaki Kanda, Gang-Hong Lee, Kimie Nomura, Keiko Ohtake, and Tomoyuki Kitagawa

Malignant transformation of a mouse liver epithelial cell line by transfection of an activated c-H-ras gene with a point mutation at codon 12
Carcinogenesis 1993 14: 1061-1063; doi:10.1093/carcin/14.5.1061 [Abstract] [PDF] [Request Permissions]  

D. Herreno-Saenz, F. E. Evans, J. Abian, and P. P. Fu

Formation of the adduct 6-(deoxyguanosin-N²-yl)-3-amino-benzo[a]pyrene from the mutagenic environmental contaminant 3-nitrobenzo[a]pyrene
Carcinogenesis 1993 14: 1065-1067; doi:10.1093/carcin/14.5.1065 [Abstract] [PDF] [Request Permissions]  

Tadayoshi Bessho, Keizo Tano, Susumu Nishimura, and Hiroshi Kasai

Induction of mutations in mouse FM3A cells by treatment with riboflavin plus visible light and its possible relation with formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA
Carcinogenesis 1993 14: 1069-1071; doi:10.1093/carcin/14.5.1069 [Abstract] [PDF] [Request Permissions]  

Birgit Rose, Parmender P. Mehta, and Werner R. Loewenstein

Gap-junction protein gene suppresses tumorigenicity
Carcinogenesis 1993 14: 1073-1075; doi:10.1093/carcin/14.5.1073 [Abstract] [PDF] [Request Permissions]  

Rosa M. Pascale, Maria M. Simile, Leonardo Gaspa, Lucia Daino, Maria A. Seddaiu, Giampaola Pinna, Monica Carta, Paola Zolo, and Francesco Feo

Alterations of ornithine decarboxylase gene during the progression of rat liver carcinogenesis
Carcinogenesis 1993 14: 1077-1080; doi:10.1093/carcin/14.5.1077 [Abstract] [PDF] [Request Permissions]  

Book review:

Book review
Carcinogenesis 1993 14: 1081; doi:10.1093/carcin/14.5.1081 [PDF] [Request Permissions]  

Editors' note:

Editors' note
Carcinogenesis 1993 14: 1082; doi:10.1093/carcin/14.5.1082 [PDF] [Request Permissions]  

Announcements:

Announcements
Carcinogenesis 1993 14: 1083; doi:10.1093/carcin/14.5.1083 [PDF] [Request Permissions]  

Author index:

Author index
Carcinogenesis 1993 14: 1084; doi:10.1093/carcin/14.5.1084 [PDF] [Request Permissions]  

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