Carcinogenesis

ACCELERATED PAPER:

Yukio Takeshima, Kouki Inai, William P. Bennett, Robert A. Metcalf, Judith A. Welsh, Shuji Yonehara, Yuzo Hayashi, Megumu Fujihara, Michio Yamakido, Mitoshi Akiyama, Shoji Tokuoka, Charles E. Land, and Curtis C. Harris

p53 mutations in lung cancers from Japanese mustards gas workers
Carcinogenesis 1994 15: 2075-2079; doi:10.1093/carcin/15.10.2075 [Abstract] [PDF] [Request Permissions]  

Vikram Jit Singh Chhatwal, Sing Shang Ngoi, Steven T.F. Chan, Yee Wen Chia, and Shabbir M. Moochhala

Aberrant expression of nitric oxide synthase in human polyps, neoplastic colonic mucosa and surrounding peritumoral normal mucosa
Carcinogenesis 1994 15: 2081-2085; doi:10.1093/carcin/15.10.2081 [Abstract] [PDF] [Request Permissions]  

K. Randerath, B. Moorthy, N. Mabon, and P. Sriram

Tamoxifen: evidence by ³²P–postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4–hydroxytamoxifen as a proximate metabolite
Carcinogenesis 1994 15: 2087-2094; doi:10.1093/carcin/15.10.2087 [Abstract] [PDF] [Request Permissions]  

ORIGINAL ARTICLES:

Akitake Ide, Keigo Yoshinaga, Takeo Iwama, and Yoshio Mishima

Bombesin enhances experimental carcinogenesis induced in rat colon by 1,2-dimethylhydrazine
Carcinogenesis 1994 15: 2095-2098; doi:10.1093/carcin/15.10.2095 [Abstract] [PDF] [Request Permissions]  

Ewan D.Booth, J.Paul Aston, Paula T.M.van den Berg, Robert A. Baan, David A. Riddick, Lara T. Wade, Alan S. Wright, and William P. Watson

Class-specific immunoadsorption purification for polycyclic aromatic hydrocarbon–DNA adducts
Carcinogenesis 1994 15: 2099-2106; doi:10.1093/carcin/15.10.2099 [Abstract] [PDF] [Request Permissions]  

M.J. Appel and R.A. Woutersen

Modulation of growth and cell turnover of preneoplastic lesions and of prostaglandin levels in rat pancreas by dietary fish oil
Carcinogenesis 1994 15: 2107-2112; doi:10.1093/carcin/15.10.2107 [Abstract] [PDF] [Request Permissions]  

Zeev A. Ronai, Scott Gradia, Karam El-Bayoumy, Shantu Amin, and Stephen S. Hecht

Contrasting incidence of ras mutations in rat mammary and mouse skin tumors induced by anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide
Carcinogenesis 1994 15: 2113-2116; doi:10.1093/carcin/15.10.2113 [Abstract] [PDF] [Request Permissions]  

James D. Yager, Joanne Zurlo, Charles H. Sewall, George W. Lucier, and Hongchin He

Growth stimulation followed by growth inhibition in livers of female rats treated with ethinyl estradiol
Carcinogenesis 1994 15: 2117-2123; doi:10.1093/carcin/15.10.2117 [Abstract] [PDF] [Request Permissions]  

David A. Wink and Jacques Laval

The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo
Carcinogenesis 1994 15: 2125-2129; doi:10.1093/carcin/15.10.2125 [Abstract] [PDF] [Request Permissions]  

Edmond J. LaVoie, Zhen-Wei Cai, Carol L. Meschter, and Eric H. Weyand

Tuimorigenic activity of fluoranthene, 2-methylfluoranthene and 3-methylfluoranthene in newborn CD-I mice
Carcinogenesis 1994 15: 2131-2135; doi:10.1093/carcin/15.10.2131 [Abstract] [PDF] [Request Permissions]  

Hari K. Bhat, Xueliang Han, Alicja Gladek, and Joachim G. Liehr

Regulation of the formation of the major diethylstilbestrol—DNA adduct and some evidence of its structure
Carcinogenesis 1994 15: 2137-2142; doi:10.1093/carcin/15.10.2137 [Abstract] [PDF] [Request Permissions]  

Brian D. Wilson, Marietta Strauss, Brenda J. Stickells, Eileen G.Hoal-van Helden, and Paul D.van Helden

An assay for 0⁶-alkylguanine-DNA alkyltransferase based on restriction endonuclease inhibition and magnetic bead separation of products
Carcinogenesis 1994 15: 2143-2148; doi:10.1093/carcin/15.10.2143 [Abstract] [PDF] [Request Permissions]  

T.P.J. Mulder, H.M.J. Roelofs, W.H.M. Peters, M.J.M. Wagenmans, C.F.M. Sier, and H.W. Verspaget

Glutathione S-transferases in liver metastases of colorectal cancer. A comparison with normal liver and primary carcinomas
Carcinogenesis 1994 15: 2149-2153; doi:10.1093/carcin/15.10.2149 [Abstract] [PDF] [Request Permissions]  

V. Corté-Vizcaíno, A. Peydró-Olaya, and A. Llombart-Bosch

Morphological and immunohistochemical support for the interstitial cell origin of oestrogen-induced kidney tumours in the Syrian golden hamster
Carcinogenesis 1994 15: 2155-2162; doi:10.1093/carcin/15.10.2155 [Abstract] [PDF] [Request Permissions]  

Makoto Asamoto, Satoru Takahashi, Katsumi Imaida, Tomoyuki Shirai, and Shoji Fukushima

Increased gap junctional intercellular communication capacity and connexin 43 and 26 expression in rat bladder carcinogenesis
Carcinogenesis 1994 15: 2163-2166; doi:10.1093/carcin/15.10.2163 [Abstract] [PDF] [Request Permissions]  

Dajun Yang, Suzanne K. Kohler, Veronica M. Maher, and J.Justin McCormick

/-sis oncogene-induced transformation of human fibroblasts into cells capable of forming benign tumors
Carcinogenesis 1994 15: 2167-2175; doi:10.1093/carcin/15.10.2167 [Abstract] [PDF] [Request Permissions]  

Donald A. Page and Gary P. Carlson

The effect of pyridine on the in vitro and in vivo metabolism of ethyl carbamate (urethane) by rat and mouse
Carcinogenesis 1994 15: 2177-2181; doi:10.1093/carcin/15.10.2177 [Abstract] [PDF] [Request Permissions]  

Greg Horesovsky, Julie Ginsler, Jeff Everitt, and Cheryl Walker

Increased susceptibility to in vitro transformation of cells carrying the Eker tumor susceptibility mutation
Carcinogenesis 1994 15: 2183-2187; doi:10.1093/carcin/15.10.2183 [Abstract] [PDF] [Request Permissions]  

N. Zhukovskaya, P. Branch, G. Aquilina, and P. Karran

DNA replication arrest and tolerance to DNA methylation damage
Carcinogenesis 1994 15: 2189-2194; doi:10.1093/carcin/15.10.2189 [Abstract] [PDF] [Request Permissions]  

K. Szyfter, K. Hemminki, W. Szyfter, Z. Szmeja, J. Banaszewski, and K. Yang

Aromatic DNA adducts in larynx biopsies and leukocytes
Carcinogenesis 1994 15: 2195-2199; doi:10.1093/carcin/15.10.2195 [Abstract] [PDF] [Request Permissions]  

Isao Sakaida, Masafumi Kubota, Kozo Kayano, Kazuyuki Takenaka, Kenji Mori, and Kiwamu Okita

Prevention of fibrosis reduces enzyme-altered lesions in the rat liver
Carcinogenesis 1994 15: 2201-2206; doi:10.1093/carcin/15.10.2201 [Abstract] [PDF] [Request Permissions]  

Ingrid Pontéen, Seog K. Kim, Astrid Gräaslund, Bengt Nordén, and Bengt Jernströ

Spectroscopic studies of the trans adducts derived from (+)- and (–)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and the oligonucleotide 5'-d(CCTATAGATATCC)
Carcinogenesis 1994 15: 2207-2213; doi:10.1093/carcin/15.10.2207 [Abstract] [PDF] [Request Permissions]  

Fumihiko Hayashi, Hiroshi Tamura, Junji Yamada, Hiroshi Kasai, and Tetsuya Suga

Characteristics of the hepatocarcinogenesis caused by dehydroepiandrosterone, a peroxisome proliferator, in male F-344 rats
Carcinogenesis 1994 15: 2215-2219; doi:10.1093/carcin/15.10.2215 [Abstract] [PDF] [Request Permissions]  

Chi-An Chen, Yen-Hui Chen, Tzer-Ming Chen, Tsang-Ming Ko, Chih-Cheng Wu, Chien-Nan Lee, and Chang-Yao Hsieh

Infrequent mutation in tumor suppressor gene p53 in gestational trophoblastic neoplasia
Carcinogenesis 1994 15: 2221-2223; doi:10.1093/carcin/15.10.2221 [Abstract] [PDF] [Request Permissions]  

Stephen Nesnow, Jeffrey Ross, Susan Beck, Jessica Lasley, Garret Nelson, Guy Lambert, Karl L. Platt, and Satish C. Agarwal

Morphological transformation and DNA adduct formation by dibenz[a,h]anthracene and its metabolites in C3H10T1/2CL8 cells
Carcinogenesis 1994 15: 2225-2231; doi:10.1093/carcin/15.10.2225 [Abstract] [PDF] [Request Permissions]  

John R. Meier and David Warshawsky

Comparison of blood protein and target organ DNA and protein binding following topical application of benzo[a]pyrene and 7H-dibenzo[c,g]carbazole to mice
Carcinogenesis 1994 15: 2233-2240; doi:10.1093/carcin/15.10.2233 [Abstract] [PDF] [Request Permissions]  

Cesar G. Fraga, Janice Onuki, Florencia Lucesoli, Etelvino J.H. Bechara, and Paolo Di Mascio

5-Aminolevulinic acid mediates the in vivo and in vitro formation of 8-hydroxy-2'-deoxyguanosine in DNA
Carcinogenesis 1994 15: 2241-2244; doi:10.1093/carcin/15.10.2241 [Abstract] [PDF] [Request Permissions]  

Lucy M. Anderson, Daniel Logsdon, Stasia Ruskie, Stephen D. Fox, Haleem J. Issaq, Robert M. Kovatch, and Charles M. Riggs

Promotion by polychlorinated biphenyls of lung and liver tumors in mice
Carcinogenesis 1994 15: 2245-2248; doi:10.1093/carcin/15.10.2245 [Abstract] [PDF] [Request Permissions]  

John Pierce Wise, Sr, Diane M. Stearns, Karen E. Wetterhahn, and Steven R. Patierno

Cell-enhanced dissolution of carcinogenic lead chromate particles: the role of individual dissolution products in clastogenesis
Carcinogenesis 1994 15: 2249-2254; doi:10.1093/carcin/15.10.2249 [Abstract] [PDF] [Request Permissions]  

Colleen H. Anna, Robert R. Maronpot, Michael A. Pereira, Julie F. Foley, David E. Malarkey, and Marshall W. Anderson

ras proto-oncogene activation in dichloroacetic add-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice
Carcinogenesis 1994 15: 2255-2261; doi:10.1093/carcin/15.10.2255 [Abstract] [PDF] [Request Permissions]  

J.M.S.van Maanen, E.J.C. Moonen, L.M. Maas, J.C.S. Kleinjans, and F.J.van Schooten

Formation of aromatic DNA adducts in white blood cells in relation to urinary excretion of 1-hydroxypyrene during consumption of grilled meat
Carcinogenesis 1994 15: 2263-2268; doi:10.1093/carcin/15.10.2263 [Abstract] [PDF] [Request Permissions]  

Edward R. Sauter, Deborah Cleveland, Bruce Trock, John A. Ridge, and Andres J.P. Klein–Szanto

p53 is overexpressed in fifty percent of pre-invasive lesions of head and neck epithelium
Carcinogenesis 1994 15: 2269-2274; doi:10.1093/carcin/15.10.2269 [Abstract] [PDF] [Request Permissions]  

Elizabeth Romach, Jana Moore, Sue Rummel, and Ellen Richie

Influence of sex and carcinogen treatment protocol on tumor latency and frequency of K-ras mutations in N-methyl-N-nitrosourea-induced lymphomas
Carcinogenesis 1994 15: 2275-2280; doi:10.1093/carcin/15.10.2275 [Abstract] [PDF] [Request Permissions]  

Neal F. Cariello, Walter W. Piegorsch, W.Thomas Adams, and Thomas R. Skopek

Computer program for the analysis of mutational spectra: application to p53 mutations
Carcinogenesis 1994 15: 2281-2285; doi:10.1093/carcin/15.10.2281 [Abstract] [PDF] [Request Permissions]  

Matthew S. Bryant, Henry F. Simmons, Robert E. Harrell, and Jack A. Hinson

2,6-Dimethylaniline—hemoglobin adducts from lidocaine in humans
Carcinogenesis 1994 15: 2287-2290; doi:10.1093/carcin/15.10.2287 [Abstract] [PDF] [Request Permissions]  

J. Ashby, J.M. Short, N.J. Jones, P.A. Lefevre, G.S. Provost, B J. Rogers, E.A. Martin, J.M. Parry, K. Burnette, B.W. GIickman, and H. Tinwell

Mutagenicity of o-anisidine to the bladder of lacI^– transgenic B6C3F1 mice: absence of ¹⁴C or ³²P bladder DNA adduction
Carcinogenesis 1994 15: 2291-2296; doi:10.1093/carcin/15.10.2291 [Abstract] [PDF] [Request Permissions]  

L. Airoldi, M. Bonfanti, L. Chiappetta, M. Lolli, C. Medana, G.De Gregorio, and R. Fanelli

Detection of O⁶-butyl- and O⁶-(4-hydroxybutyl)guanine in urothelial and hepatic DNA of rats given the bladder carcinogen N-nitrosobutyl(4-hydroxybutyl)amine
Carcinogenesis 1994 15: 2297-2301; doi:10.1093/carcin/15.10.2297 [Abstract] [PDF] [Request Permissions]  

Li-Hua Zhang and Dag Jenssen

Studies on intrachromosomal recombination in SP5/V79 Chinese hamster cells upon exposure to different agents related to carcinogenesis
Carcinogenesis 1994 15: 2303-2310; doi:10.1093/carcin/15.10.2303 [Abstract] [PDF] [Request Permissions]  

mice Akiyoshi Yoshida, Takanori Harada, Shim-mo Hayashi, Ikuo Mori, Hiroaki Miyajima, and Keizo Maita

Endometrial carcinogenesis induced by concurrent oral administration of ethylenethiourea and sodium nitrite in mice
Carcinogenesis 1994 15: 2311-2318; doi:10.1093/carcin/15.10.2311 [Abstract] [PDF] [Request Permissions]  

Razmik Mirzayans, Susan Cubitt, Louise Enns, Kashayar Karimian, Bruno Radatus, Samim Hirani-Hojatti, Keshava Murthy, and Malcom C. Paterson

Comparative genotoxicity of 2,3'-O-cyclocytidine, ß-xylocytidine and 1-ß-D-arabinofuranosylcytosine in human tumor cell lines
Carcinogenesis 1994 15: 2319-2324; doi:10.1093/carcin/15.10.2319 [Abstract] [PDF] [Request Permissions]  

Catherine Chaumontet, Valérie Bex, Isabelle Gaillard-Sanchez, Christine Seillan-Heberden, Marc Suschetet, and Paule Martel

Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells
Carcinogenesis 1994 15: 2325-2330; doi:10.1093/carcin/15.10.2325 [Abstract] [PDF] [Request Permissions]  

Thomas H. Broschard, Manfred Wiessler, Claus-Wilhelm von der Lieth, and Heinz H. Schmeiser

Translesional synthesis on DNA templates containing site-specifically placed deoxyadenosine and deoxyguanosine adducts formed by the plant carcinogen aristolochic acid
Carcinogenesis 1994 15: 2331-2340; doi:10.1093/carcin/15.10.2331 [Abstract] [PDF] [Request Permissions]  

Diane F.Birt, Jill C.Pelling, James Anderson, and Tracy Barnett

Consumption of reduced-energy/low-fat diet or constant-energy/high-fat diet during mezerein treatment inhibited mouse skin tumor promotion
Carcinogenesis 1994 15: 2341-2345; doi:10.1093/carcin/15.10.2341 [Abstract] [PDF] [Request Permissions]  

R.-M. Liu, V. Vasiliou, H. Zhu, J.-L. Duh, M.W. Tabor, A. Puga, D.W. Nebert, M. Sainsbury, and H.G. Shertzer

Regulation of [Ah] gene battery enzymes and glutathione levels by 5,10-dihydroindeno[l,2-b]indole in mouse hepatoma cell lines
Carcinogenesis 1994 15: 2347-2352; doi:10.1093/carcin/15.10.2347 [Abstract] [PDF] [Request Permissions]  

W.Elaine Hardman and Ivan L. Cameron

Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas
Carcinogenesis 1994 15: 2353-2361; doi:10.1093/carcin/15.10.2353 [Abstract] [PDF] [Request Permissions]  

Yao-ping Lu, Richard L. Chang, You-rong Lou, Mou-Tuan Huang, Harold L. Newmark, Kenneth R. Reuhl, and Allan H. Conney

Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis
Carcinogenesis 1994 15: 2363-2370; doi:10.1093/carcin/15.10.2363 [Abstract] [PDF] [Request Permissions]  

SHORT COMMUNICATION:

Jan Erik Paulsen, Inger-Lise Steffensen, Ellen Namork, and Jan Alexander

Scanning electron microscopy of aberrant crypt foci in rat colon
Carcinogenesis 1994 15: 2371-2373; doi:10.1093/carcin/15.10.2371 [Abstract] [PDF] [Request Permissions]  

Young-Joon Surh, Amy Liem, James A. Miller, and Steven R. Tannenbaum

5-Sulfooxymethylfurfural as a possible ultimate mutagenic and carcinogenic metabolite of the Maillard reaction product, 5-hydroxymethylfurfural
Carcinogenesis 1994 15: 2375-2377; doi:10.1093/carcin/15.10.2375 [PDF] [Request Permissions]  

Tsuneo Masui, Ihmin Don, Nobuyasu Takada, Kumiko Ogawa, Tomoyuki Shirai, and Shoji Fukushima

p53 mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine
Carcinogenesis 1994 15: 2379-2381; doi:10.1093/carcin/15.10.2379 [Abstract] [PDF] [Request Permissions]  

Li-Chuan Chen, Linda Sly, and Luigi M. De Luca

High dietary retinoic acid prevents malignant conversion of skin papillomas induced by a two-stage carcinogenesis protocol in female SENCAR mice
Carcinogenesis 1994 15: 2383-2386; doi:10.1093/carcin/15.10.2383 [Abstract] [PDF] [Request Permissions]  

Sumiyo Endo, Manfred Metzler, and Ludwig Hieber

Nonrandom karyotypic changes in a spontaneously immortalized and tumourigenic Syrian hamster embryo cell line
Carcinogenesis 1994 15: 2387-2391; doi:10.1093/carcin/15.10.2387 [PDF] [Request Permissions]  

Corrigendum:

P. D. Josephy, H. L. Lord, and V. A. Snieckus

Dimethylnitrosamine genotoxicity: does N-acetyltransferase activity play a role?
Carcinogenesis 1994 15: 2390; doi:10.1093/carcin/15.10.2390 [PDF] [Request Permissions]  

Author index:

Author index
Carcinogenesis 1994 15: 2392-2393; doi:10.1093/carcin/15.10.2392 [PDF] [Request Permissions]  

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